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Infertility affects an estimated 50 million women worldwide and has
a wide range of causes including eating disorders, smoking,
chemotherapy, diseases such as STIs, as well as genetic factors and
malformations. The preliminary assessment and diagnosis involves a
potentially broad array of lab and imaging tests, physical
examination and potentially genetic tests, after which a management
plan is selected depending on the woman’s age, the cause(s) and
duration of the infertility. Female Infertility: Core Principles
and Clinical Management provides clinicians with a comprehensive
understanding of how best to overcome infertility using the various
treatment options now available. The book opens with an
introduction to the anatomy and physiology of the female
reproductive system before describing the assessment and
investigative tools used in primary and secondary healthcare
settings. Subsequent chapters describe how to secure optimum
functionality of the ovaries, the measurement of ovarian
reserves, stimulation protocols and the process of oogenesis and
oocyte collection. Given their potential adverse impact on the
quality of oocytes and implantation, dedicated chapters focus on
the treatment of polycystic ovarian syndrome and endometriosis.
Concluding chapters address fast moving and future technologies,
including the use of pluripotent stem cells for treating different
medical conditions; the management of mitochondrial disease and the
transplantation of cryopreserved ovaries. Highly illustrated and
written by a team of international experts in the field, Female
Infertility: Core Principles and Clinical Management serves as an
essential resource for all clinicians, nurses and clinical
scientists who specialise in reproductive medicine, gynecology,
oncology, infertility and embryology.
Maintaining consistent and reliably high success rates is a daily
challenge for every IVF laboratory. This step-by-step guide is an
essential aid in navigating the complex maze of physical, chemical,
biological, and logistic parameters that underpin successful gamete
and embryo culture: temperature, pH, osmolality, gas supplies, air
quality, light exposure, infections, managing supplies, personnel,
as well as overall quality control. Numerous real-life
troubleshooting case reports are presented, identifying all aspects
necessary for troubleshooting. Process maps and flow charts
accompanying each chapter offer a logical and systematic approach
to problem solving in the laboratory. This is an essential resource
for scientists in assisted reproductive technology and specialists
in reproductive biology and medicine, helping IVF clinics to
achieve the dream of every infertile couple: the birth of a healthy
child.
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