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I am very happy and honoured to have so many famous contrib utors
from around the world presenting their knowledge and experience in
this book, including Dr. Rufer who, as early as 1967, attempted to
improve the pressure-volume curve of a child dying from RDS using
dried surfactant from dogs; Drs. Enhorn ing and Robertson who were
the first to treat rabbit fetuses with surfactant replacement and
impressively demonstrated that sur factant improved lung mechanics;
and Dr. Fujiwara who at the end of the 1970's had already
successfully treated the first babies with surfactant replacement
and published this work al ready in 1980. Thus, the idea of
surfactant replacement therapy is now more or less 20 years old and
almost 10 years have passed since the first publication by Dr.
Fujiwara of his impressive clinical results. Up to now (September,
1988) about 2,200 babies have been treated worldwide with tracheal
instillation of surfactant, with most promising results. The type
of surfactant used varies from pure natural extracts from bovine or
pig lungs, to surfactant extracted from human amniotic fluid, to
pure phospholipids. To date, however, there is still no surfactant
commercially available (except in Japan), in spite of the fact that
it is urgently awaited by neonatologists and intensive care doctors
throughout the world. This volume is based on the contributions
presented at the international congress on Surfactant Replacement
Therapy which was held in Rotterdam, The Netherlands, in November
1987."
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