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The successful previous volume on this topic provided a detailed
benchwork manual for the most commonly used animal models of acute
neurological injuries including cerebral ischemia, hemorrhage,
vasospasm, and traumatic brain and spinal cord injuries. Animal
Models of Acute Neurological Injuries II: Injury and Mechanistic
Assessments aims to collect chapters on assessing these disorders
from cells and molecules to behavior and imaging. These
comprehensive assessments are the key for understanding disease
mechanisms as well as developing novel therapeutic strategies to
ameliorate or even prevent damages to the nervous system. Volume 2
examines global cerebral ischemia, focal cerebral ischemia, and
neonatal hypoxia-ischemia, as well as intensive sections covering
traumatic brain injury and spinal cord injury. Designed to provide
both expert guidance and step-by-step procedures, chapters serve to
increase understanding in what, why, when, where, and how a
particular assessment is used. Accessible and essential, Animal
Models of Acute Neurological Injuries II: Injury and Mechanistic
Assessments will be useful for trainees or beginners in their
assessments of acute neurological injuries, for experienced
scientists from other research fields who are interested in either
switching fields or exploring new opportunities, and for
established scientists within the field who wish to employ new
assessments.
The successful previous volume on this topic provided a detailed
benchwork manual for the most commonly used animal models of acute
neurological injuries including cerebral ischemia, hemorrhage,
vasospasm, and traumatic brain and spinal cord injuries. Animal
Models of Acute Neurological Injuries II: Injury and Mechanistic
Assessments aims to collect chapters on assessing these disorders
from cells and molecules to behavior and imaging. These
comprehensive assessments are the key for understanding disease
mechanisms as well as developing novel therapeutic strategies to
ameliorate or even prevent damages to the nervous system. Volume 1
examines general assessments in morphology, physiology,
biochemistry and molecular biology, neurobehavior, and
neuroimaging, as well as extensive sections on subarachnoid
hemorrhage, cerebral vasospasm, and intracerebral hemorrhage.
Designed to provide both expert guidance and step-by-step
procedures, chapters serve to increase understanding in what, why,
when, where, and how a particular assessment is used. Accessible
and essential, Animal Models of Acute Neurological Injuries II:
Injury and Mechanistic Assessments will be useful for trainees or
beginners in their assessments of acute neurological injuries, for
experienced scientists from other research fields who are
interested in either switching fields or exploring new
opportunities, and for established scientists within the field who
wish to employ new assessments.
Despite numerous recent studies and exciting discoveries in the
field, only limited treatment is available today for the victims of
acute neurological injuries. Animal Models of Acute Neurological
Injuries provides a standardized methodology manual designed to
eliminate the inconsistent preparations and variability that
currently jeopardizes advances in the field. Contributed by top
experts and many original developers of the models, each chapter
contains a step-by-step, proven procedure and visual aids covering
the most commonly used animal models of neurological injury in
order to highlight the practical applications of animal models
rather than the theoretical issues. This intensive volume presents
its readily reproducible protocols with great clarity and
consistency to best aid neuroscientists and neurobiologists in
laboratory testing and experimentation. Comprehensive and
cutting-edge, Animal Models of Acute Neurological Injuries is an
ideal guide for scientists and researchers who wish to pursue this
vital course of study with the proficiency and precision that the
field requires.
Despite numerous recent studies and exciting discoveries in the
field, only limited treatments are available today for the victims
of acute brain and spinal cord injuries. Animal Models of Acute
Neurological Injuries, Second Edition, provides a standardized
methodology manual designed to eliminate the inconsistent
preparations and variability that often inhibit advances in this
specialized research field. In the 10 years since publication of
the first edition of this book, some animal models have become
obsolete, some have stood the test of time, and newer models have
emerged to enhance our knowledge of acute neurological injuries.
The second edition continues to offer the research community tested
approaches for this area of investigation. As with the first
edition, top experts have developed and contributed these animal
models. The book's focus remains hands-on, practical applications
of the models, rather than a theoretical approach. Each chapter
contains a proven procedure enhanced by clear figures,
illustrations, or videos. This new edition presents its readily
reproducible protocols with clarity and consistency to best aid
neuroscientists and neurobiologists. As with the first edition, the
second edition is comprehensive and cutting-edge. Animal Models of
Acute Neurological Injuries, Second Edition, is an ideal guide for
research professionals, at all stages of their careers, who wish to
pursue this vital course of study with the proficiency and
precision required by the field.
Provides the latest information on imaging technologies and
transdermal delivery in skin disorders This important, timely book
covers the latest understanding about today's major skin disorders,
the development of imaging technologies for skin diagnosis, and the
applications of micro/nano-technologies for the treatment of skin
complications. It also places great emphasis on the critical role
that interdisciplinary science occupies to achieve the requisite
level of understanding of skin conditions and their management,
which is essential to creating technologies that work. Imaging
Technologies and Transdermal Delivery in Skin Disorders starts by
outlining the structural characteristics of skin and skin
appendages. It then discusses the key pathways involved in skin
growth and development. Clinical presentations, pathophysiological
mechanisms, and current clinical practices used to treat diseases
affecting the skin are then introduced. Common preclinical models
used for studying the mechanisms of diverse skin diseases,
validation of novel therapeutic targets, and screening of new drugs
to treat these diseases are also covered. The book examines the
latest imaging technologies for understanding in vivo skin changes,
as well as technologies such as high-resolution ultrasound imaging,
quantitative Magnetic Resonance Imaging, high-resolution Optical
Coherence Tomography, and emerging hybrid-imaging modalities. It
concludes with chapters introducing emerging drug delivery
technologies and potential future innovative developments. *
Presents up-to-date knowledge of the skin biology and pathologies *
Introduces advancements in the topic of imaging technology for
tracing the drug delivery process, which is rarely systematically
reported by other counterparts * Covers the latest development in
three inter-related directions of drug delivery, imaging, and skin
disease intersect for skin research * Provides an overview of the
latest development of diagnostic and therapeutic technologies for
skin diseases Imaging Technologies and Transdermal Delivery in Skin
Disorders will be of great interest to analytical chemists,
materials scientists, pharmaceutical chemists, clinical chemists,
biotechnologists, bioengineers, cosmetics industry, and
dermatologists.
The successful previous volume on this topic provided a detailed
benchwork manual for the most commonly used animal models of acute
neurological injuries including cerebral ischemia, hemorrhage,
vasospasm, and traumatic brain and spinal cord injuries. Animal
Models of Acute Neurological Injuries II: Injury and Mechanistic
Assessments aims to collect chapters on assessing these disorders
from cells and molecules to behavior and imaging. These
comprehensive assessments are the key for understanding disease
mechanisms as well as developing novel therapeutic strategies to
ameliorate or even prevent damages to the nervous system. Volume 1
examines general assessments in morphology, physiology,
biochemistry and molecular biology, neurobehavior, and
neuroimaging, as well as extensive sections on subarachnoid
hemorrhage, cerebral vasospasm, and intracerebral hemorrhage.
Designed to provide both expert guidance and step-by-step
procedures, chapters serve to increase understanding in what, why,
when, where, and how a particular assessment is used. Accessible
and essential, Animal Models of Acute Neurological Injuries II:
Injury and Mechanistic Assessments will be useful for trainees or
beginners in their assessments of acute neurological injuries, for
experienced scientists from other research fields who are
interested in either switching fields or exploring new
opportunities, and for established scientists within the field who
wish to employ new assessments.
The successful previous volume on this topic provided a detailed
benchwork manual for the most commonly used animal models of acute
neurological injuries including cerebral ischemia, hemorrhage,
vasospasm, and traumatic brain and spinal cord injuries. Animal
Models of Acute Neurological Injuries II: Injury and Mechanistic
Assessments aims to collect chapters on assessing these disorders
from cells and molecules to behavior and imaging. These
comprehensive assessments are the key for understanding disease
mechanisms as well as developing novel therapeutic strategies to
ameliorate or even prevent damages to the nervous system. Volume 2
examines global cerebral ischemia, focal cerebral ischemia, and
neonatal hypoxia-ischemia, as well as intensive sections covering
traumatic brain injury and spinal cord injury. Designed to provide
both expert guidance and step-by-step procedures, chapters serve to
increase understanding in what, why, when, where, and how a
particular assessment is used. Accessible and essential, Animal
Models of Acute Neurological Injuries II: Injury and Mechanistic
Assessments will be useful for trainees or beginners in their
assessments of acute neurological injuries, for experienced
scientists from other research fields who are interested in either
switching fields or exploring new opportunities, and for
established scientists within the field who wish to employ new
assessments.
A comprehensive overview exploring the biological applications of
chiral nanomaterials Chirality has been the centerpiece of many
multidisciplinary fields within the broader umbrella of the
sciences. Recent advancements in nanoscience have spurred a growing
interest in the dynamic field of chiral nanomaterials. In
particular, the recent breakthroughs in chiral nanocrystals have
presented an intriguing avenue whose potential application may
address some key issues at the heart of nanosciences. While little
attention has been focused on the biological implications of such
advances, this arena is attracting theoretical and applicative
interests. Seeking to provide a thorough introduction to the field
as well as fill this gap in scholarship, Chiral Nanoprobes for
Biological Applications first provides a comprehensive review of
the state-of-the-art development of strong chiroptical
nanomaterials, describing how a synthesis and self-assembly
approach can enable one to design and create a number of functional
chiral nanomaterials. From there, the authors discuss the
biological applications of chiral nanomaterials, such as
extracellular bioanalysis, intracellular bioanalysis, and chiral
recognition, as well as photothermal and photodynamics therapy. In
doing so, the book seeks emphasize the potential in
multidisciplinary approaches to this up-and-coming field. Chiral
Nanoprobes for Biological Applications readers will also find: A
particular emphasis on milestones achieved for key chiral
nanoprobes research from the last five years A discussion of future
research directions A helpful guide for new researchers and
established professionals alike Chiral Nanoprobes for Biological
Applications is a useful reference for materials scientists,
biochemists, protein chemists, stereo chemists, polymer chemists,
and physical chemists. It is also a useful tool for libraries.
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