This edited collection explores the topic of constitutionalism across borders in the struggle against terrorism, analyzing how constitutional rules and principles relevant in the field of counter-terrorism move across borders. Various chapters underline how constitution-like norms consolidate at the level of international and supranational organizations as a limit to the exercise of public power in the field of counter-terrorism policy, especially counter-terrorism financing. Other chapters examine the extraterritorial application of constitutional rights and the migration of constitutional norms - or anti-constitutional practices - from one state to another. Still others consider how transnational cooperation between states in areas such as intelligence gathering and data sharing may call for updating domestic constitutional law rules or for new international law compacts entrenching rights across borders. What emerges is a picture of the complex interplay of constitutional law, international law, criminal law and the law of war, creating webs of norms and regulations that apply in the struggle against terrorism conducted across increasingly porous borders. The book will be of particular interest to academics and graduate or post-graduate students working in the fields of constitutional law, international law, human rights, comparative law and national security law. It may also be of interest to practitioners concerned with national security, counterterrorism, and related questions of individual rights. Contributors: O. Bassok, D. Cole, K. Cooper, J. Daskal, E. de Wet, B. Dickson, A. Ejima, S. Ellmann, F. Fabbrini, L. Garlicki, J. Hafetz, V.J. Jackson, C.C. Murphy, M. Scheinin, K.L. Scheppele, A. Su, C. Walker

This one-of-a-kind maze book set in a galaxy far, far away is a fun, interactive way to explore the Star WarsTM universe. Expert maze creator and lifelong Star Wars fan Sean C. Jackson brings the saga to life through more than 30 beautifully illustrated mazes of iconic scenes and locations ranging from the forest moon of Endor to Bespin’s Cloud City, the dark side planet of Exegol, Jabba’s palace, pod races, clone armies, and much more. Each full-color maze includes notes about the environment and special bonus elements to find hidden along the way. Star Wars fans of all ages will enjoy racing through the corridors of the Death Star, scavenging inside a fallen star destroyer on Jakku, searching the rocky cliffs of Ahch-To, and much more. •    EXPLORE A GALAXY FAR, FAR AWAY: Immerse yourself in a brand new way when you explore your favorite Star Wars locations via exciting mazes. •    ACCOMPLISH MISSIONS WITH EACH MAZE: Each of the dozens of unique mazes comes with its own mission that’s accomplished by finishing the maze, such as “Return to the base to escort the last transport off planet,� “Take the smuggler Han Solo back to your ship,� and “Locate Jedi Master Yoda in the mysterious swamp.� •    EXTRA, FINDABLE ITEMS IN EACH MAZE: In addition to the maze itself, each includes other game activities or elements to find. •    BEAUTIFULLY ILLUSTRATED AND REPLAYABLE: The gorgeously detailed full color mazes may be solved by pen or pencil, but using a non-writing item to follow the paths leaves the book ready to replay. © & TM LUCASFILM LTD. Used Under Authorization.

Explore exciting iconic locations and scenes with your favorite comics characters in this interactive, all-ages book of mighty Marvel mazes. Accomplish missions and locate key objects along the way while discovering the mysteries of Doctor Strange's Sanctum Sanctorum, the S.H.I.E.L.D. Helicarrier, Wakanda, Asgard, and Doctor Doom's Castle. Follow the Guardians of the Galaxy to Knowhere, help the Avengers fight the Skrulls aboard their flagship, face fearsome Sentinels with the X-Men in days of future past, and more! Brought to life by expert maze creator Sean C. Jackson, each full-color maze is a playful visual delight for Marvel fans everywhere.

It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, "How can we use computational methods to improve the success rate in drug development?" Computer Techniques in Preclinical and Clinical Drug Development shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.

As this century draws to a close and the new one approaches, the United States is still struggling with serious and persistent social problems. These troubling dilemmas, including poverty, homelessness, discrimination, and severe inequity, afflict some subgroups of the population more than others, and it is the plight of these at-risk groups-childr

Sean C. Jackson has been illustrating and exploring mazes for his own enjoyment for more than 30 years. Inspired by art, architecture and the natural world, his colourfully detailed mazes offer imaginative and meditative journeys through village streets, garden vistas, island habitats, castle grounds, scenic towns and gravity-defying surreal situations-each encouraging the mind to wander while following the paths. This large-format collection features nearly 50 absorbing single-page and full-spread mazes, sequenced with increasing complexity and includes inventive bonuses such as mazes with two paths to follow and a maze that runs on the inside covers from front to back. Solutions are provided, but for those seeking mindful activity or hours of puzzle decoding entertainment, getting there will be half the fun.

Once a mere appendage to constitutional law proper, research in comparative constitutional law has burgeoned in recent decades. Indeed, a growing tendency towards international borrowing and harmonization has been marked in many jurisdictions (even, tentatively, the United States), but it has not been uncontroversial, or uncontested. Now, this new collection from Routledge's Critical Concepts in Law series meets the need for an authoritative reference work to help researchers and students navigate and make better sense of an abundance of scholarship in comparative constitutional law. The collection is made up of four volumes which bring together the best and most influential canonical and cutting-edge thinking. Topics include constitution-making and amendment; the different structural components of constitutional governance (such as the relationship of legislatures to courts and the effects of different methods of judicial oversight); the interaction of constitutional law with transnational sources of law; and theoretical and practical aspects of constitutional legitimacy. With a full index, and thoughtful introductions, newly written by the learned editor, Comparative Constitutional Law traces the field's development and highlights the challenges for future explorations. The collection will be valued by legal scholars-as well as by political philosophers and theorists-as a vital and enduring resource.

Since the late 1400s, tea drinkers in the Orient and the West have been passionate about teapots in ever growing numbers. Over 445 beautiful color images display a wide range of international teapots, from antique to contemporary. Porcelain, stoneware, silver, copper, brass, iron, pewter, tin, wood, and glass are shown from around the world. Children's tea sets, miniatures, musical, figural, whimsical, seasonal, advertising, commemorative, and souvenir teapots are all included. A brief history of tea is provided along with values. Join the collectors who look for teapots in exotic places and enjoy their use with every cup consumed.

As this century draws to a close and the new one approaches, the United States is still struggling with serious and persistent social problems. These troubling dilemmas, including poverty, homelessness, discrimination, and severe inequity, afflict some subgroups of the population more than others, and it is the plight of these at-risk groups. This book provides keen and powerful insights into the problems affecting the "disadvantaged" populations of this nation. The contributors' informed perspectives are critically important if we are to comprehend the scale and complexity of the obstacles to achieving an "equitable society" in the twenty-first century.

Visually stunning, informative, and broad in scope, this comprehensive overview gathers the works of renowned still-life painter Scott Fraser. Beautiful full color images of his body of work are accompanied by companion drawings and detailed close-ups, demonstrating the artist's approach to painting. A summary of his work, an interview of Fraser by artist Robert C. Jackson, and an extensive chronology of works allow the reader to explore the path of growth and development that took him from a landscape painter in the 1980s to the nationally renowned still-life painter that Fraser is today. His intense scrutiny of objects is revealed in full-page details of several important works. The over 200 drawings and paintings included here also reveal how Fraser's passion for art history is a strongly recurring theme, often demonstrating itself in surprising ways. This book offers valuable insights for collectors, museums, students, academics, artists, and everyone interested in contemporary still life painting.

It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, "How can we use computational methods to improve the success rate in drug development?" Computer Techniques in Preclinical and Clinical Drug Development shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.

Viral infections of the nervous system are important because they are associated with high morbidity and mortality. A variety of pathogenetic mechanisms are involved in these infections and an understanding of the pathogenesis is essential in understanding the diagnostic and clinical management aspects of the disease. Specialized investigations are often necessary for definitive diagnosis, although a presumptive diagnosis should often be suspected on the basis of the clinical features. Many of the chapters in this book are written by neurologists who are experts in basic science research of their topic in addition to active clinical practice in their specialty.

The author thoroughly describes and analyzes the most significant systems methodologies-organizations as systems, ' hard, soft, cybernetic, and critical-and demonstrates the complementary strengths of different systems approaches.

Twenty five years ago, in 1964, The Operational Research Society's first International Conference (held at Gonville and Caius College, Cambridge) took as its theme "Operational Research and the Social Sciences." The Conference sessions were organised around topics such as: Organisations and Control; Social Effects of Policies; Conflict Resolution; The Systems Concept; Models, Decisions and Operational Research. An examination of the published proceedings (J.R.Lawrence ed., 1966, Operational Research and the Social Sciences, Tavistock, London) reveals a distinct contrast between the types of contribution made by the representatives of the two academic communities involved. Nevertheless, the Conference served to break down some barriers, largely of ignorance about the objects, methods and findings of each concern. In the ensuing twenty five years, although debate has continued about the relationship between OR and the social sciences, mutual understanding has proved more difficult to achieve than many must have hoped for in 1964.

The theme ofthe conference at which the papers in this book were presented was'Systems Thinking in Europe'. Members of the United Kingdom Systems Society (UKSS) were conscious that the systems movementflourishes notonly in the UK, America and the Antipodes, but also in continental Europe, both East and West, and in the USSR, a nation increasingly being welcomed by the European comity. Membership of the UKSS had not perhaps had the opportunity, however, of hearing important new ideas from continental Europe, and this conference provided an opportunity to do so. Some interesting papers are to be found here from both the West and the East, if the editors may be forgiven for perpetuating what may be an increasingly irrelevant dichotomy. One lesson to be learned from this conference, though, is that systems thinking is truly international. This is not to say that there is one systems paradigm unifonnly applied, however. Perhaps the core of systems thinking is that one is interested in complex 'wholes' with emergent properties, to which cybernetic ideas can be applied. Examples of such systems thinking can be found in these proceedings, for example in the section entitled "Applications of Systems Thinking." Attempts to bring about change with these ideas, however, have given rise to a diversity of approaches, as is evidenced by the papers dealing with the application of methodologies in the 'hard' and 'soft' systems traditions.

Viral infections of the nervous system are important because they are associated with high morbidity and mortality. A variety of pathogenetic mechanisms are involved in these infections and an understanding of the pathogenesis is essential in understanding the diagnostic and clinical management aspects of the disease. Specialized investigations are often necessary for definitive diagnosis, although a presumptive diagnosis should often be suspected on the basis of the clinical features. Many of the chapters in this book are written by neurologists who are experts in basic science research of their topic in addition to active clinical practice in their specialty.

Medical ethics is a difficult and controversial field and that part of it dealing with reproductive medicine is no exception. Our first conference on philosophical ethics in reproductive medicine (PERM 1) in 1988 discussed many of the controversies in this field. The acclaim it received encouraged us to organise PERM 2 but choosing a relevant and topical programme was a clairvoyant challenge in its own right. Since PERM 1 we have seen a number of developments, in the UK and internationally, that have thrown the problems that society must face into sharp relief. Drawing on the expertise of contributors from science, many medical specialities, philosophy, theology and economics, we have sought to address the issues raised by these new developments, as well as a number of long-standing issues that remain as contentious as ever, but of undiminished significance. On the scientific front, the long-predicted technique of embryo biopsy and diagnosis is now a reality. This has prompted the inclusion of some of the topics addressed by this second conference.

Systems Prospects is a record of the papers presented at the first con ference organised by the United Kingdom Systems Society (UKSS), held at Thwaite Hall, Hull University (UK), on the dates 12th-15th July, 1988. The UKSS originally came together in 1978 as the Barford Group (the first meetings were held in the town of Barford), comprising academics from the four institutions that incorporated departments which primarily were con cerned with developing the theory and practice of so-called systems scienc- namely Aston University, City University, Lancaster University and the Open University. The meetings of the Barford Group were deemed to be successful, so much so that a decision was made to widen its horizons to incorporate more generally those of the United Kingdom systems community (a diffuse number of academics and practitioners) - hence the title UKSS. The society, ten years later, is extant and has achieved new levels of success in the last few years in terms of rising membership and international reputation. The membership is now drawn from a wide variety of academic and commercial and industrial organisations, and from most reaches of the nation. There is also an international contingent in the membership. It is right that there should be such diversity since the UKSS is founded on the notion of equality (of creed, sex, race, class and so on *** ). This community is "glued" together by the Society's own publication, Systemist, as well as through workshops and now this conference.

Systems Thinking is a new paradigm set to revolutionize management practice in the 21st century. Systems Approaches to Management is the most comprehensive guide available to the application of this new paradigm in the field of management. It, * Traces the emergence of holistic thinking in disciplines such as biology, control engineering, sociology and the natural sciences * Details and provides a critique, based upon social theory, of the range of systems approaches, methodologies, models and methods * Offers numerous case studies to illustrate systems thinking applied to management * Introduces critical systems thinking' as a coherent framework that brings unity to the diversity of different systems approaches and advises managers, consultants, scholars and students on their use * Provides an accessible source of inspiration for managers, management consultants, scholars and students GBP/LISTGBP Covers chaos and complexity theory, the learning organization, system dynamics, living systems theory, soft systems methodology, interactive management, interactive planning, total systems intervention, autopoiesis, management cybernetics, the viable system model, operations research (hard and soft), systems analysis, systems engineering, general system theory, sociotechnical systems thinking, the fifth discipline, social systems design, team syntegrity, postmodern systems thinking, critical systems thinking, and much more. Considers the work of Ackoff, Banathy, Beer, Capra, Checkland, Churchman, Eden, Emery, Flood, Forrester, Friend, Freire, Jackson, Jantsch, Linstone, Luhmann, Mason, Maturana, Miller, Mitroff, Prigonine, Rosenhead, Senge, Stacey, Trist, Ulrich, Varela, Vickers, von Bertalanffy, Warfield, Wheatley, Wiener, and many more.

Systems Thinking is a new paradigm set to revolutionize management practice in the 21st century. Systems Approaches to Management is the most comprehensive guide available to the application of this new paradigm in the field of management. It, * Traces the emergence of holistic thinking in disciplines such as biology, control engineering, sociology and the natural sciences * Details and provides a critique, based upon social theory, of the range of systems approaches, methodologies, models and methods * Offers numerous case studies to illustrate systems thinking applied to management * Introduces critical systems thinking' as a coherent framework that brings unity to the diversity of different systems approaches and advises managers, consultants, scholars and students on their use * Provides an accessible source of inspiration for managers, management consultants, scholars and students GBP/LISTGBP Covers chaos and complexity theory, the learning organization, system dynamics, living systems theory, soft systems methodology, interactive management, interactive planning, total systems intervention, autopoiesis, management cybernetics, the viable system model, operations research (hard and soft), systems analysis, systems engineering, general system theory, sociotechnical systems thinking, the fifth discipline, social systems design, team syntegrity, postmodern systems thinking, critical systems thinking, and much more. Considers the work of Ackoff, Banathy, Beer, Capra, Checkland, Churchman, Eden, Emery, Flood, Forrester, Friend, Freire, Jackson, Jantsch, Linstone, Luhmann, Mason, Maturana, Miller, Mitroff, Prigonine, Rosenhead, Senge, Stacey, Trist, Ulrich, Varela, Vickers, von Bertalanffy, Warfield, Wheatley, Wiener, and many more.

The author thoroughly describes and analyzes the most significant systems methodologies-organizations as systems, ' hard, soft, cybernetic, and critical-and demonstrates the complementary strengths of different systems approaches.

'An essential guide' (Dr Mark Hyman, author of Young Forever) to navigating life with the cognitive and mental health impairments that often accompany Long Covid. Early in the Covid-19 pandemic, the shocking mortality figures obscured the fact that death is not the only adverse outcome associated with the virus. Today, as many as 30 to 50 percent of Covid-19 survivors still experience symptoms long after their acute illness has passed, with problems especially prominent in the areas of cognitive and mental health. For long haulers, this struggle with Long Covid has irrevocably changed their lives. Many have lost their ability to work, attend school, or look after their children. They often feel misunderstood and dismissed by others. Their once-full lives are now filled only with doctors' appointments that seem more and more futile. In Clearing the Fog, neuropsychologist Dr. James C. Jackson offers people suffering from Long Covid and their families a roadmap to help them manage their 'new normal'. Focussing on cognitive impairment and mental health issues, he shows readers: - the ways they can manifest and disrupt - suggestions for how and when to seek professional evaluations - science-based treatment options and strategies - information on navigating health care systems and disability insurance - validation and hope as patients wrestle with their new diagnosis In addition, Dr Jackson shares his own experience with chronic illness , relating to long haulers with vulnerability and compassion. Through moving stories, as well as hands-on guidance, Clearing the Fog will help long haulers understand their current situation while offering multiple ways to address it, make sense of it, and move through it with the goal of thriving instead of merely surviving.

Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.