Tying together technological and conceptual advances of the past decade, this seminal book introduces the novel approach of chemical cytometry -- the biochemical analysis of cell constituents at the single cell level. As such, it combines recently developed methods for the handling of single cells, the separation of their components, and the detection and analysis of biomolecular species with application examples from cell biology, neurobiology and molecular medicine.
The editor has succeeded in acquiring contributions from the recognized leaders in the field, resulting in a complete and authoritative overview for both developers as well as users of these new methods.

Recent studies into how our genes are turned on and off have raised many questions about our lifestyle choices, but no market has more questions than women contemplating pregnancy. Very few doctors have the answers because the study of preconception is so new. Often doctors have as many questions as their patients. This book from a leading expert in the field is the first and only book that will answer them. It gives women a step-by-step plan that lays the groundwork not just for an easy pregnancy and a healthy baby, but for the child's health throughout the his/her entire life. As Dr. Lu shows us, the impact of being healthy and free of toxins at the time of conception can be huge both for the mother and for her baby. His plan shows us how we can help prevent life-threatening conditions like pregnancy-related high blood pressure (preeclampsia) and gestational diabetes, as well as how to minimize the likelihood of many childhood conditions from allergies to ADHD. It may even help prevent the child from developing illnesses like cancer later in life.

Debates between realists, communitarians, and cosmopolitans about the ethics of intervention in world politics are disciplined by competing models of the public/private distinction. Taking insights and controversies from feminist political theory, Lu focuses on this construct to illuminate alternative images of 'sovereignty as privacy' and 'sovereignty as responsibility', and to identify new ethical challenges arising from the increased agency of private global civil society actors, and their uneasy relationship with the world of states in contexts of 'humanitarian intervention'.

Taking insights and controversies from feminist political theory, Lu looks to illuminate alternative images of 'sovereignty as privacy' and 'sovereignty as responsibility', and to identify new challenges arising from the increased agency of private global civil society, and their relationship with the world of states.

The science and applied approaches of enzyme inhibition in drug discovery and development

Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, "Enzyme Inhibition in Drug Discovery and Development" examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development.

With chapters written by over fifty leading experts in their fields, "Enzyme Inhibition in Drug Discovery and Development" fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the "good" inhibitions--desirable pharmacological effects--and "bad" inhibitions--drug-drug interactions and toxicity. The book discusses:

The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment

The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug-drug interactions

The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway

Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.