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Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, 31 (English, German, Paperback, Softcover reprint of the original 1st ed. 1974)
N. H. Andersen, F. Brady, C.M. Harris, M. Harris, E. Hecker, …
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R1,520
Discovery Miles 15 200
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Ships in 18 - 22 working days
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The verrucarins and roridins are secondary metabolites of the soil
fungi Myrothecium verrucaria (Albertini et Schweinitz) Ditmar ex
Fries and Myrothecium roridum Tode ex Fries. The species
Myrothecium belongs to the fungi imperfecti, order of Moniliales,
family Tubercularia- ceae (30, 17, 32). The distinction between
these and other closely related fungal species is difficult. It has
been studied and discussed by various authors (82, 16, 55, 75, 62,
43). Myrothecium species are parasitic on leaves of Gardenia,
tomatoes, violets, kidney beans, snapdragons and other common
plants. They are also found on decaying tissue and in soil. It was
known earlier that cultures of the two species mentioned exhibit
cellulolytic properties due to the presence of a very active
cellulase which was used for the treatment of cellulose during the
production of textiles [for leading references see (42, 66)]. The
first investigation of the secondary metabolites of these micro-
organisms was carried out by BRIAN and MCGOWAN (16). They isolated
a crystalline compound, designated as glutinosin and assigned the
formula C4sH60016, from cultures of Metarrhizium glutinosum S.
Pope, which in fact is a Myrothecium species (82, 55). Glutinosin
exhibited anti- fungal activity. Eight years later BOWDEN and
SCHANTZ (14) described the isolation and characterization of a
dermatitic or skinirritating crystal- line compound melting at 38 ,
and possessing the formula C H 04, 1s 22 from culture filtrates of
Myrothecium verrucaria. They suspected the presence of additional
biologically active substances.
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