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Over the last decade the environmental setup has changed for
synthetic organ ic chemists to a considerable degree. So far
synthetic organic chemistry had focussed on methodology development
which mainly deals with the develop ment of new reactions as well
as new reagents and catalysts. These ought to be able to perform
preferentially highly selective (chemo-, regio-and stereose
lective) synthetic transformations, often applied in the context of
complex and highly functionalized molecules. Except for the
synthesis of peptides and oligonucleic acids, little attention has
been spent on the question of how synthesis can be carried out in
an envi ronment of sophisticated technologies which includes
improved hardware. While peptides and oligonucleotides are
conveniently prepared by Merrifield's solid phase technique,
solution phase synthesis of most other synthetic targets have not
been substantially replaced by this solid phase approach. Without
discussing this aspect in detail it is obvious that today a
renaissance of sophis ticated solution phase synthesis can be
noted. Immobilization of reagents and particularly catalysts, an
old concept indeed, recently returned back onto the stage and this
is addressed in this volume of Topics in Current Chemistry in a
broader sense."
Over the last decade the environmental setup has changed for
synthetic organ ic chemists to a considerable degree. So far
synthetic organic chemistry had focussed on methodology development
which mainly deals with the develop ment of new reactions as well
as new reagents and catalysts. These ought to be able to perform
preferentially highly selective (chemo-, regio-and stereose
lective) synthetic transformations, often applied in the context of
complex and highly functionalized molecules. Except for the
synthesis of peptides and oligonucleic acids, little attention has
been spent on the question of how synthesis can be carried out in
an envi ronment of sophisticated technologies which includes
improved hardware. While peptides and oligonucleotides are
conveniently prepared by Merrifield's solid phase technique,
solution phase synthesis of most other synthetic targets have not
been substantially replaced by this solid phase approach. Without
discussing this aspect in detail it is obvious that today a
renaissance of sophis ticated solution phase synthesis can be
noted. Immobilization of reagents and particularly catalysts, an
old concept indeed, recently returned back onto the stage and this
is addressed in this volume of Topics in Current Chemistry in a
broader sense."
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