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As a clinical discipline blood transfusion encompasses enormous
vista, vary ing from biotechnology to molecular biology, from
plasma products, cell biology and growth factors to interleukines.
Growth of knowledge in this field has been rapid, and expertise is
now required to be mastered and renewed in translating these ideas
for patient care. Various types of cells could be harvested -
progenitor stem cells derived from bone marrow or from circulating
blood as a source for transplants; in the hemostatic armoury
platelets could be used prophylactically; granulocytes and
mononuclear cells are available for treatment of infections or
immune modulations. However, their therapeutic use carries
potential complications including graft versus host disease and
CMV-infection. Prevention of such complications by irradiation and
by removal of immunocompetent leukocytes are important issues.
Thus, production of such therapeutic materials ought to address the
issues at the earliest, to eliminate those problems while adhering
to the con cept of high quality; the impact of storing platelets
for longer periods by using improved plastic containers or storing
almost indefinitely in frozen state should be explored. Rapid
progress in cell culture techniques and bio technology have
enriched the transfusion medicine armoury with lympho kines,
interferons and cell colony growth factors which have great
potentials for enhancement of basic knowledge as well as
considerable therapeutic applications in patients.
As a clinical discipline blood transfusion encompasses enormous
vista, vary ing from biotechnology to molecular biology, from
plasma products, cell biology and growth factors to interleukines.
Growth of knowledge in this field has been rapid, and expertise is
now required to be mastered and renewed in translating these ideas
for patient care. Various types of cells could be harvested -
progenitor stem cells derived from bone marrow or from circulating
blood as a source for transplants; in the hemostatic armoury
platelets could be used prophylactically; granulocytes and
mononuclear cells are available for treatment of infections or
immune modulations. However, their therapeutic use carries
potential complications including graft versus host disease and
CMV-infection. Prevention of such complications by irradiation and
by removal of immunocompetent leukocytes are important issues.
Thus, production of such therapeutic materials ought to address the
issues at the earliest, to eliminate those problems while adhering
to the con cept of high quality; the impact of storing platelets
for longer periods by using improved plastic containers or storing
almost indefinitely in frozen state should be explored. Rapid
progress in cell culture techniques and bio technology have
enriched the transfusion medicine armoury with lympho kines,
interferons and cell colony growth factors which have great
potentials for enhancement of basic knowledge as well as
considerable therapeutic applications in patients."
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