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The Fifth International Lymphokine Workshop was convened in
Clearwater Beach, Florida, January 11-15, 1987. The theme chosen
for the meeting was 'The Molecular Basis of Lymphokine Action,"
which reflected the opinion of the organizers as to how far the
field had moved since the first Lymphokine Workshop only eleven
years ago. As was evident at the last Lymphokine Workshop held in
1985, the contribution of molecular biology, particularly in the
cloning of lymphokine genes, continues to play an important role in
clarifying the structure of lymphokines, providing recombinant
(read "pure") proteins for biological studies, and suggesting
directions for studies of the molecular basis of lymphokine
activity. The most recent lymphokines to yield to molecular cloning
meth odology were the B-cell growth and differentiation factors, in
partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One
of the surprises from this research is the broad spectrum of
activities that can be attributed to this molecule, aside from its
effects on B-cells, thus perhaps justifying its being called an
interleukin. The interleukin 2 symposium demonstrated that even in
a well-established research area, controversy and excitement can
continue, when evidence was presented by several investigators
indicating the presence of a second "converter" protein that
changes the affinity of the now classical Tac antigen from a low to
a high affinity IL-2 receptor."
The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel,
St. Louis, MO, August 28-31, 1982; 240 scientists participated in
the Workshop. The man uscripts compiled in this book describe the
state of the art concerning Ir genes. Although the notion of Ir
Genes: Past, Present, and Future has not been ad dressed
specifically by each author, the reader is certain to get this
flavor from the contributions. In this Preface, we have tried to
summarize some of the salient ob servations and discussions from
the Workshop. The mUltiple genes of the I region have been defined
traditionally by serolog ical analysis of intra-H-2 recombinant
mice and the pattern of immune responses to certain antigens
developed by these recombinant mice. The application of sev eral
new techniques, such as gene cloning and DNA sequencing, production
of T and B cell hybridomas, and development of cloned T cell lines
has changed this tradition and introduced a new phase into the
analysis of the I region, Ia antigens, and Ir genes."
The Fifth International Lymphokine Workshop was convened in
Clearwater Beach, Florida, January 11-15, 1987. The theme chosen
for the meeting was 'The Molecular Basis of Lymphokine Action,"
which reflected the opinion of the organizers as to how far the
field had moved since the first Lymphokine Workshop only eleven
years ago. As was evident at the last Lymphokine Workshop held in
1985, the contribution of molecular biology, particularly in the
cloning of lymphokine genes, continues to play an important role in
clarifying the structure of lymphokines, providing recombinant
(read "pure") proteins for biological studies, and suggesting
directions for studies of the molecular basis of lymphokine
activity. The most recent lymphokines to yield to molecular cloning
meth odology were the B-cell growth and differentiation factors, in
partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One
of the surprises from this research is the broad spectrum of
activities that can be attributed to this molecule, aside from its
effects on B-cells, thus perhaps justifying its being called an
interleukin. The interleukin 2 symposium demonstrated that even in
a well-established research area, controversy and excitement can
continue, when evidence was presented by several investigators
indicating the presence of a second "converter" protein that
changes the affinity of the now classical Tac antigen from a low to
a high affinity IL-2 receptor."
The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel,
St. Louis, MO, August 28-31, 1982; 240 scientists participated in
the Workshop. The man uscripts compiled in this book describe the
state of the art concerning Ir genes. Although the notion of Ir
Genes: Past, Present, and Future has not been ad dressed
specifically by each author, the reader is certain to get this
flavor from the contributions. In this Preface, we have tried to
summarize some of the salient ob servations and discussions from
the Workshop. The mUltiple genes of the I region have been defined
traditionally by serolog ical analysis of intra-H-2 recombinant
mice and the pattern of immune responses to certain antigens
developed by these recombinant mice. The application of sev eral
new techniques, such as gene cloning and DNA sequencing, production
of T and B cell hybridomas, and development of cloned T cell lines
has changed this tradition and introduced a new phase into the
analysis of the I region, Ia antigens, and Ir genes."
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