Medicinal Chemistry of Anticancer Drugs, Third Edition provides an updated resource for students and researchers from the point-of-view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. The new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theragnostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point-of-view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references, reviews and primary literature.

Everything there is to know about avocados is here: ancient origins, amazing health properties, restorative cosmetic uses, and a recipe collection far beyond the tried and true. This book features a fresh visual design aesthetic that reflects the creative sensibility of Mexican contemporary art, graphic design, atmospheric photography, and street style. Recipes cover everything from guacamole in many variations, salads, unusual sides, many permutations of avocado toast even toastless avocado sandwiches as well as less well-known and offbeat uses. The book also explores avocado butter and oil; detoxifying smoothies; rejuvenating cosmetic salves and masks, and much more. Practical matters are also addressed: an avocado overview by type; storage tips; preserving the brilliant green flesh from browning; ripening immature fruits; and safety tips for slicing and de-pitting. Avocados are grown in Mediterranean climates globally and dominate social media, hip restaurant menus, and health-based diets, but this is the first book paying tribute to the superfruit s deep roots as a native, Mexican heritage food.

Delivering successful procurement programs has helped businesses like IKEA, Tesla and Nike maximize the potential of their resources and gain the competitive advantage. Learn how to develop similar strategies, that meet the needs of the business, customers and suppliers, and lead their implementation using insights from the experts in procurement strategy. Leading Procurement Strategy provides readers with a complete overview of the skills, knowledge and tools needed to implement a successful procurement strategy. The expert author team of Carlos Mena, Remko van Hoek, and Martin Christopher present practical advice and guidance underpinned by academic theory and supported by an extensive range of real-world case studies including IBM, IKEA, John Deere, NASA, Nike and Tesla. Readers are shown how to develop, deliver and sustain procurement performance with clear and accessible guidance. The third edition offers the latest insights into the future of procurement and digitalization, updates on green and socially responsible procurement and a revised structure. The key issues affecting the procurement function are covered and tips for developing the best practices in teams are found throughout.

Part of the new Clinical Approach series—which focuses on key topics in cardiology—this pragmatic, comprehensive guide is intended for residents, practitioners, advanced practice nurses, and physician assistants, and covers arterial, venous, and lymphatic diseases. Easy-to-read chapters are written by clinical experts in interventional cardiology, interventional radiology, vascular surgery, and podiatry, and begin with helpful quick-reference summaries. Includes up-to-date information on imaging, complications, and limb salvaging, as well as pharmacology therapies such as drug-coated stents. Clinical algorithms help you make well-informed diagnostic, treatment, and disease management decisions. Guidance on the most current equipment and technology designed to ensure patients are treated with the most efficacious modalities available. Includes illustrations, photos, and other images. Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.