Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms.

This book introduces the current concepts of molecular mechanisms in synaptic plasticity and provides a comprehensive overview of cutting-edge research technology used to investigate the molecular dynamics of the synapses. It explores current concepts on activity-dependent remodeling of the synaptic cytoskeleton and presents the latest ideas on the different forms of plasticity in synapses and dendrites. Synaptic Plasticity in Health and Disease not only supplies readers with extensive knowledge on the latest developments in research, but also with important information on clinical and applied aspects. Changes in spine synapses in different brain disease states, so-called synaptopathies, are explained and described by experts in the field. By outlining basic research findings as well as physiological and pathophysiological impacts on synaptic plasticity, the book represents an essential state-of-the-art work for scientists in the fields of biochemistry, molecular biology and the neurosciences, as well as for doctors in neurology and psychiatry alike.

Economic Policy and Human Rights presents a powerful critique of three decades of neoliberal economic policies, assessed from the perspective of human rights norms. In doing so, it brings together two areas of thought and action that have hitherto been separate: progressive economics concerned with promoting economic justice and human development; and human rights analysis and advocacy. Focussing on in-depth comparative case studies of the USA and Mexico and looking at issues such as public expenditure, taxation and international trade, the book shows that heterodox economic analysis benefits greatly from a deeper understanding of a human rights framework. This is something progressive economists have often been skeptical of, regarding it as too deeply entrenched in 'Western' norms, discourses and agendas. Such a categorical rejection is unwarranted. Instead, human rights norms can provide an invaluable ethical and accountability framework, challenging a narrow focus on efficiency and growth. A vital book for anyone interested in human rights and harnessing economics to create a better world.

This book introduces the current concepts of molecular mechanisms in synaptic plasticity and provides a comprehensive overview of cutting-edge research technology used to investigate the molecular dynamics of the synapses. It explores current concepts on activity-dependent remodeling of the synaptic cytoskeleton and presents the latest ideas on the different forms of plasticity in synapses and dendrites. Synaptic Plasticity in Health and Disease not only supplies readers with extensive knowledge on the latest developments in research, but also with important information on clinical and applied aspects. Changes in spine synapses in different brain disease states, so-called synaptopathies, are explained and described by experts in the field. By outlining basic research findings as well as physiological and pathophysiological impacts on synaptic plasticity, the book represents an essential state-of-the-art work for scientists in the fields of biochemistry, molecular biology and the neurosciences, as well as for doctors in neurology and psychiatry alike.

Le Isole Galleggianti fluttuano da sempre in un mare di nebbia scintillante dalle origini misteriose. I nostri eroi devono scoprire la causa della nebbia, navigando in un mare solcato da navi pirata e imbarcazioni dei goblin, esploranto otto differenti isole e tre dungeon per giungere alla verit ... se la tua lama sar pi veloce ed affilata di quella dei rivali! Quella che hai in mano la seconda avventura ufficiale de La Spada Nera. Per giocare avrai bisogno di una copia del regolamento ufficiale, dei dadi poliedrici e dei tuoi amici o parenti.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.

Economic Policy and Human Rights presents a powerful critique of three decades of neoliberal economic policies, assessed from the perspective of human rights norms. In doing so, it brings together two areas of thought and action that have hitherto been separate: progressive economics concerned with promoting economic justice and human development; and human rights analysis and advocacy. Focussing on in-depth comparative case studies of the USA and Mexico and looking at issues such as public expenditure, taxation and international trade, the book shows that heterodox economic analysis benefits greatly from a deeper understanding of a human rights framework. This is something progressive economists have often been skeptical of, regarding it as too deeply entrenched in 'Western' norms, discourses and agendas. Such a categorical rejection is unwarranted. Instead, human rights norms can provide an invaluable ethical and accountability framework, challenging a narrow focus on efficiency and growth. A vital book for anyone interested in human rights and harnessing economics to create a better world.