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Site-specific mutagenesis of DNA, developed some thirty years ago,
has proven to be one of the most important advances in biology. By
allowing the site-specific replacement of any amino acid in a
protein with one of the other nineteen amino acids, it ushered in
the new era of "Protein Engineering". The field of protein
engineering has, however, evolved rapidly since then and the last
fifteen years have witnessed remarkable advances through the use of
new chemical, biochemical and molecular biological tools towards
the synthesis and manipulation of proteins. The chapters included
in this book reflect the rapid evolution of protein engineering and
its many applications in basic research, biotechnology, material
sciences and therapy. This book will provide the reader with an
introduction to state-of the-art concepts and methods and will be
of use to anyone interested in the study of proteins, in academia
as well as in industry.
Site-specific mutagenesis of DNA, developed some thirty years ago,
has proven to be one of the most important advances in biology. By
allowing the site-specific replacement of any amino acid in a
protein with one of the other nineteen amino acids, it ushered in
the new era of "Protein Engineering." The field of protein
engineering has, however, evolved rapidly since then and the last
fifteen years have witnessed remarkable advances through the use of
new chemical, biochemical and molecular biological tools towards
the synthesis and manipulation of proteins. The chapters included
in this book reflect the rapid evolution of protein engineering and
its many applications in basic research, biotechnology, material
sciences and therapy. This book will provide the reader with an
introduction to state-of the-art concepts and methods and will be
of use to anyone interested in the study of proteins, in academia
as well as in industry.
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