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This is a well thought-out, highly practical text covering
contemporary 'in vitro' techniques for drug absorption studies.
Starting at the molecular level of investigation, it continues with
cell monolayer models (both primary and cell lines) and culminates
with in situ techniques as a final testing format. In addition,
chapters on high-throughput assays, in vitro-in vivo correlation,
bioinformatics and regulatory issues are covered, giving a
comprehensive overview of available models and techniques.
Moreover, an appendix consisting of a number of practical protocols
is available online, updated as needed, and should prove very
helpful to apply the techniques directly to the benchside.
In the last 15 years, a great number of cell- or tissue-based in
vitro models have been introduced into the biopharmaceutics arena.
These models mimic the different biological barriers that a drug
has to overcome to finally reach its target organ/cell/receptor.
These in vitro models have been found very useful in not only
characterising the permeability behaviour of drugs molecules in
epithelial and endothelial tissues, but also studying drug delivery
systems for improved delivery and enhanced absorption. Compared to
the complex in vivo situation, in vitro models offer a fast,
convenient approach with cost advantages most of times. Most
importantly, they can be standardised and automatised to be
applicable to the high-throughput screening. Starting at the
molecular level of studies, continuing with cell monolayer models
(both primary and cell lines) and in situ techniques as a final
testing format, the book provides a practical approach to
contemporary in vitro techniques for drug absorption studies. In
addition, chapters on high-throughput assays, in vitro-in vivo
correlation, bioinformatics and regulatory issues are covered,
giving a comprehensive overview of available models and techniques.
Moreover, an appendix comprised with a number of practical
protocols is available online, updated as needed, should prove very
helpful to apply the techniques directly to the benchside.
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