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Only five years ago, nobody in his right mind would have consid
ered publishing a book on reeler as a model for brain develop ment.
Although this interesting mutation has been with us for half a
century, it is fair to say that, in spite of a wave of enthusiasm
in the late sixties and early seventies, generated primarily by
Sidman, Caviness and colleagues, studies of reeler mice fell pro
gressively out of fashion during the next two decades. All that
changed almost overnight when the cloning of the reeler gene,
dubbed reelin, was reported in Tom Curran's laboratory in 1995. The
fact that the same gene was identified at the same time
independently by two other groups using positional cloning sug
gested strongly that reelin was the right candidate. Although the
key experiments of transgenic rescue have not been made (and
perhaps will never be), the equation "reeler is reelin" has been
established beyond reasonable doubt, as alterations of the reelin
gene and/or its expression have been found in at least five alleles
of reeler and in the mutation Shaking Rat Kawasaki (SRK), an
ortholog of reeler."
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