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Post-translational modifications serve many different purposes in
several cellular processes such as gene expression, protein folding
and transport to appropriate cell compartment, protein-lipid and
protein-protein interactions, enzyme regulation, signal
transduction, cell proliferation and differentiation, protein
stability, recycling and degradation. Although several-hundred
different modifications are known, the significance of many of them
remains unknown. The enormous versatility of the modifications
which frequently alter the physico-chemical properties of the
respective proteins represents an extraordinary challenge in
understanding their physiological role. Since essential cellular
functions are regulated by protein modifications, an improvement of
current understanding of their meaning might allow new avenues to
prevent and/or alleviate human and animal diseases.
Post-translational modifications serve many different purposes in
several cellular processes such as gene expression, protein folding
and transport to appropriate cell compartment, protein-lipid and
protein-protein interactions, enzyme regulation, signal
transduction, cell proliferation and differentiation, protein
stability, recycling and degradation. Although several-hundred
different modifications are known, the significance of many of them
remains unknown. The enormous versatility of the modifications
which frequently alter the physico-chemical properties of the
respective proteins represents an extraordinary challenge in
understanding their physiological role. Since essential cellular
functions are regulated by protein modifications, an improvement of
current understanding of their meaning might allow new avenues to
prevent and/or alleviate human and animal diseases.
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