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The origin of life is one of the biggest unsolved scientific
questions. This book deals with the formation and first steps of
the chemical evolution of nucleic acids, including the chemical
roots behind the origin of their components from the simplest
sources in a geochemical context. Chemical evolution encompasses
the chemical processes and interactions conducive to self-assembly
and supramolecular organization, leading to an increase of
complexity and the emergence of life. The book starts with a
personal account of the pioneering work of Stanley Miller and
Jeffrey Bada on the Chemistry of Origins of Life and how the
development of organic chemistry beginning in the 19th century led
to the emergence of the field of prebiotic chemistry, situated at
the frontier between organic, geo- and biochemistry. It then
continues reviewing in tutorial manner current central topics
regarding the organization of nucleic acids: the origin of
nucleobases and nucleosides, their phosphorylation and
polymerization and ultimately, their self-assembly and
supramolecular organization at the inception of life.
The origin of life is one of the biggest unsolved scientific
questions. This book deals with the formation and first steps of
the chemical evolution of nucleic acids, including the chemical
roots behind the origin of their components from the simplest
sources in a geochemical context. Chemical evolution encompasses
the chemical processes and interactions conducive to self-assembly
and supramolecular organization, leading to an increase of
complexity and the emergence of life. The book starts with a
personal account of the pioneering work of Stanley Miller and
Jeffrey Bada on the Chemistry of Origins of Life and how the
development of organic chemistry beginning in the 19th century led
to the emergence of the field of prebiotic chemistry, situated at
the frontier between organic, geo- and biochemistry. It then
continues reviewing in tutorial manner current central topics
regarding the organization of nucleic acids: the origin of
nucleobases and nucleosides, their phosphorylation and
polymerization and ultimately, their self-assembly and
supramolecular organization at the inception of life.
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