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This book is the outcome of an international conference, held at
the Aviya Sonesta Hotel in Eilat, Israel, on March 24-27, 1985.
This was the 30th in a series of the annual OHOLO Conferences,
sponsored by the Israel Institute for Biological Research.
Participants in this Conference consisted of scientists from four
teen countries; represented a broad spectrum of research interests;
and included a well-balanced representation from academia, clinical
institutions and pharmaceutical industry. The book includes talks,
poster sessions, and a comprehensive general discussion, all from
the proceedings of this conference. In the interest of assuring a
rapid publication of the novel infor mation reviewed, this book has
been prepared in camera-ready format. We are cognizant of the fact
that several typographical errors may exist in the text, and that
there are variations in style and typeface of the var ious
chapters. This, we felt, was a reasonable compromise for the sake
of speed and efficient transmission of valuable scientific
information. No body is perfect . **** The success of the
conference, and hence the quality of this book are attributable to
the extensive efforts of a large number of extremely capable
individuals. These include members of the Scientific Organizing
Committee, and the Technical staff of the OHOLO Organization. Of
course, the conference could not have succeeded without the high
quality of the presentations, and the enthusiastic participation of
the contributing scientists.
Alzheimer's disease is a primary neurodegenerative disease whose
incidence and prevalence is rapidly approaching epidemic
proportions. A major reason for this is that man is living longer
than he has ever lived before and the likelihood of contracting the
disease is significantly greater within the elderly portion of the
population. The problem becomes even more acute in the light of
recent estimates which predict that the number of people living
beyond the age of 65 is expected to continue to increase. The
impact of these statistics on the family and the health care
industry in terms of time, effort and cost are staggering. A recent
report issued by the Michigan Task Force on Alzheimer's Disease and
Related Conditions (1987) effectively underscores this last point.
"Each person with a dementing disease requires an average of seven
years of care, either at home or in a residential care facility.
Care provided at home is estimated to cost about $12,000 annually,
for a total of $84,000 per person. This is a conservative figure,
however, because many persons with dementia spend their last few
years in a nursing home at an average 'cost of $22,000 per year,
and some spend from 10 to 15 years in a nursing home, for a total
cost of $220,000 to $330,000.
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