This issue is part two of a two-part issue involving the emerging field of stem cell transplantation.? Articles include: BMT for profound T cell Dysfunction (combined immunodeficiency); BMT and other management of HLA Class II deficiency; Genetic manipulation of stem cells - Past and future; Gene therapy for ADA deficiency; Haemopoietic stem cell biology; and Indications for BMT.

This issue is part one of a two-part issue involving the emerging field of stem cell transplantation for immunodeficiency disorders. Topics include: Past experience and future directions of BMT; Stem cell selection and manipulation; Advantage for BMT at < 3months in SCID; Infections during and post transplantations (and other complications).