An extraordinary new book of investigative reporting seven years in the making. "Down by the River" chronicles the bewildering and brutal events surrounding a still-unsolved 1995 murder in El Paso, Texas.

Poor clinical trial designs result in failed studies wasting research funds and limiting the advancement of cures for disorders. Clinical Trial Design Challenges in Mood Disorders outlines classic problems researchers face in designing clinical trials and discusses how best to address them for the most definitive and generalizable results. Traditional trial designs are included as well as novel analytic techniques. The book examines information on high placebo response, the generalizability of studies conducted in the developing world, the duration of maintenance studies, and the application of findings into clinical practice. With representation from contributors throughout the world and from academia, industry, regulatory agencies, and advocacy groups, this book will contribute toward improved clinical trial design and valid, precise, and reliable answers about what works better and faster for patients.

In this unprecedented and chilling monologue, a repentant Mexican hitman tells the unvarnished truth about the war on drugs on the American. El Sicario is the hidden face of America's war on drugs. He is a contract killer who functioned as a commandante in the Chihuahuan State police, who was trained in the US by the FBI, and who for twenty years kidnapped, tortured and murdered people for the drug industry at the behest of Mexican drug cartels. He is a hit man who came off the killing fields alive. He left the business and turned to Christ. And then he decided to tell the story of his life and work. Charles Bowden first encountered El Sicario while reporting for the book "Murder City." As trust between the two men developed, Bowden bore witness to the Sicario's unfolding confession, and decided to tell his story. The well-spoken man that emerges from the pages of "El Sicario" is one who has been groomed by poverty and driven by a refusal to be one more statistic in the failure of Mexico. He is not boastful, he claims no major standing in organized crime. But he can explain in detail not only torture and murder, but how power is distributed and used in the arrangement between the public Mexican state and law enforcement on the ground - where terror and slaughter are simply tools in implementing policy for both the police and the cartels. And he is not an outlaw or a rebel. He is the state. When he headed the state police anti-kidnapping squad in Juarez, he was also running a kidnapping ring in Juarez. When he was killing people for money in Juarez, he was sharpening his marksmanship at the Federal Police range. Now he lives in the United States as a fugitive. One cartel has a quarter million dollar contract on his head. Another cartel is trying to recruit him. He speaks as a free man and of his own free will - there are no charges against him. He is a lonely voice - no one with his background has ever come forward and talked. He is the future - there are thousands of men like him in Mexico and there will be more in other places. He is the truth no one wants to hear.

A passionate advocate for preserving wilderness and fighting the bureaucratic and business forces that would destroy it, Edward Abbey (1927-1989) wrote fierce, polemical books such as Desert Solitaire and The Monkey Wrench Gang that continue to inspire environmental activists. In this eloquent memoir, his friend and fellow desert rat Charles Bowden reflects on Abbey the man and the writer, offering up thought-provoking, contrarian views of the writing life, literary reputations, and the perverse need of critics to sum up "what he really meant and whether any of it was truly up to snuff." The Red Caddy is the first literary biography of Abbey in a generation. Refusing to turn him into a desert guru, Bowden instead recalls the wild man in a red Cadillac convertible for whom liberty was life. He describes how Desert Solitaire paradoxically "launched thousands of maniacs into the empty ground" that Abbey wanted to protect, while sealing his literary reputation and overshadowing the novels that Abbey considered his best books. Bowden also skewers the cottage industry that has grown up around Abbey's writing, smoothing off its rougher (racist, sexist) edges while seeking "anecdotes, little intimacies . . . pieces of the True Beer Can or True Old Pickup Truck." Asserting that the real essence of Abbey will always remain unknown and unknowable, The Red Caddy still catches gleams of "the fire that from time to time causes a life to become a conflagration."

The magnificent second novel from the legendary author of One Flew Over the Cuckoo's Nest.

Following the astonishing success of his first novel, One Flew Over the Cuckoo's Nest, Ken Kesey wrote what Charles Bowden calls "one of the few essential books written by an American in the last half century." This wild-spirited tale tells of a bitter strike that rages through a small lumber town along the Oregon coast. Bucking that strike out of sheer cussedness are the Stampers. Out of the Stamper family's rivalries and betrayals Ken Kesey has crafted a novel with the mythic impact of Greek tragedy.

For more than seventy years, Penguin has been the leading publisher of classic literature in the English-speaking world. With more than 1,700 titles, Penguin Classics represents a global bookshelf of the best works throughout history and across genres and disciplines. Readers trust the series to provide authoritative texts enhanced by introductions and notes by distinguished scholars and contemporary authors, as well as up-to-date translations by award-winning translators.

In the promised land of the Sunbelt, people come by the thousands to escape the crush of Eastern cities and end up duplicating the very world they have fled. Can the land remain unchanged? In Blue Desert, Charles Bowden presents a view of the Southwest that seeks to measure how rapid growth has taken its toll on the land. Writing with a reporter's objectivity and a desert rat's passion, Bowden takes us into the streets as well as the desert to depict not a fragile environment but the unavoidable reality of abuse, exploitation, and human cruelty. Blue Desert shows us the Sunbelt's darker side as it has developed in recent times-where "the land always makes promises of aching beauty and the people always fail the land"-and defies us to ignore it. Blue Desert has no boundaries, no terrain, no topographical coordinates; it is a state of mind inescapable to one who sees change and knows that nothing can be done to stop it.

While politicians and pundits endlessly debate immigration policy, U.S. Border Patrol agents put their lives on the line to enforce immigration law. In a day's work, agents may catch a load of narcotics, apprehend groups of people entering the country illegally, and intercept a potential terrorist. Their days often include rescuing aliens from death by thirst or murder by border bandits, preventing neighborhood assaults and burglaries, and administering first aid to accident victims, and may involve delivering an untimely baby or helping stranded motorists. As Bill Broyles and Mark Haynes sum it up, "Border Patrol is a hero job," one that too often goes unrecognized by the public. Desert Duty puts a human face on the Border Patrol. It features interviews with nineteen active-duty and retired agents who have worked at the Wellton, Arizona, station that watches over what is arguably the most perilous crossing along the border-a sparsely populated region of the Sonoran Desert with little water and summer temperatures that routinely top 110 DegreesF. The agents candidly discuss the rewards and frustrations of holding the line against illegal immigrants, smugglers, and other criminals-while often having to help the very people they are trying to thwart when they get into trouble in the desert. As one agent explains, "The thrill is tracking 'em up before they die. It's a rough ol' way to go-run outta water in this desert."

Joey O'Shay is not the real name of the narcotics agent in an unnamed city in the center of the country. But Joey O'Shay exists. The nearly three hundred drug busts he has orchestrated over more than two decades are real, too; if the drug war were a declared war, O'Shay would have a Silver Star.
With nerves and mastery worthy of his subject, Charles Bowden follows O'Shay as he sets in motion his latest conquest, a $50 million heroin deal that originates in Colombia and has federal agents sitting at attention from Los Angeles to Washington, D.C., to New York City. As it unfolds, O'Shay reveals the unerring instinct and ceaseless vigilance that have led him through minefields and brought down kingpins. But now they have led him to a place where it isn't so clear who the heroes are or what the fight has been for. And still the warrior fights on, in a murky and unforgiving landscape readers will not be able to forget.

The Santa Catalina Mountains north of Tucson-whose summit is called Frog Mountain by the Tohono O'odham-offers up to the citizens of the basins below a wilderness in their own backyard. When it was first published in 1987, Frog Mountain Blues documented the creeping sprawl of new development up the Catalinas' foothills. Today, that development is fully visible, but Charles Bowden's prescience of the urgency to preserve and protect a sacred recreational space remains as vivid as ever. Accompanied by Jack W. Dykinga's photographs from the original work, this book continues to convey the natural beauty of the Catalinas and warns readers that this unique wilderness could easily be lost. As Alison Hawthorne Deming writes in the new foreword, ""Frog Mountain Blues continues to be an important book for learning to read this place through the eyes of experience and history, and Bowden remains a sobering voice for facing our failures in protecting what we love in this time of global destruction, for taking seriously the power of language to set ourselves right again with the enormous task of living with purpose and presence and care on the land.

Ciudad Juarez lies just across the Rio Grande from El Paso, Texas. A once-thriving border town, it now resembles a failed state. Infamously known as the place where women disappear, its murder rate exceeds that of Baghdad or Mogadishu.

In "Murder City," Charles Bowden has written an extraordinary account of what happens when a city disintegrates. Interweaving stories of its inhabitants--a raped beauty queen, a repentant hit man, a journalist fleeing for his life--with a broader meditation on the town's descent into anarchy, Bowden reveals how Juarez's culture of violence will not only worsen but inevitably spread north.

"I will make bold to say that Bowden is America's most alarming writer. Just when you think you've heard it all you learn you haven't in the most pungent manner possible. . . . With The Charles Bowden Reader in hand you get a taste of it all, and any literate resident or visitor should want this book. It will lead them back to a close, alarming reading of the entire oeuvre. It is to ride in a Ferrari without brakes. There's lots of oxygen but no safe way to stop. . . . Read him at your risk. You have nothing to lose but your worthless convictions about how things are." -Jim Harrison, from the foreword From his first book, Killing the Hidden Waters, to his most recent, Murder City: Cuidad Juarez and the Global Economy's New Killing Fields, Charles Bowden has been sounding an alarm about the rapacious appetites of human beings and the devastation we inflict on the natural world we arrogantly claim to possess. His own corner of the world, the desert borderlands between the United States and Mexico, is Bowden's prime focus, and through books, magazine articles, and newspaper journalism he has written eloquently about key issues roiling the border-drug-related violence that is shredding civil society, illegal immigration and its toll on human lives and the environment, destruction of fragile ecosystems as cities sprawl across the desert and suck up the limited supplies of water. This anthology gathers the best and most representative writing from Charles Bowden's entire career. It includes excerpts from his major books-Killing the Hidden Waters, Blue Desert, Desierto: Memories of the Future, Blood Orchid,Blues for Cannibals, A Shadow in the City, Inferno, Exodus, and Some of the Dead Are Still Breathing-as well as articles that appeared in Esquire, Harper's, Mother Jones, and other publications. Imbued with Bowden's distinctive rhythm and lyrical prose, these pieces also document his journey of exploration-a journey guided, in large part, by the question posed in Some of the Dead Are Still Breathing: "How do we live a moral life in a culture of death?" This is no metaphor; Bowden is referring to the people, history, animals, and ecosystems that are being extinguished in the onslaught of twenty-first-century culture. The perfect introduction to his work, The Charles Bowden Reader is also essential for those who know him well and want to see the whole panorama of his passionate, intense writing.

In the quarter-century since his first book, Killing the Hidden Waters, was published in 1977, Charles Bowden has become one of the premier writers on the American environment, rousing a generation of readers to both the wonder and the tragedy of humanity's relationship with the land. Revisiting his earliest work with a new introduction, "What I Learned Watching the Wells Go Down," Bowden looks back at his first effort to awaken people to the costs and limits of using natural resources through a simple and obvious example-water. He drives home the point that years of droughts, rationing, and even water wars have done nothing to slake the insatiable consumption of water in the American West. Even more timely now than in 1977, Killing the Hidden Waters remains, in Edward Abbey's words, "the best all-around summary I've read yet, anywhere, of how our greed-driven, ever-expanding urban-industrial empire is consuming, wasting, poisoning, and destroying not only the resource basis of its own existence, but also the vital, sustaining basis of life everywhere."

In this unprecedented and chilling monologue, a repentant Mexican hitman tells the unvarnished truth about the war on drugs on the American. El Sicario is the hidden face of America's war on drugs. He is a contract killer who functioned as a commandante in the Chihuahuan State police, who was trained in the US by the FBI, and who for twenty years kidnapped, tortured and murdered people for the drug industry at the behest of Mexican drug cartels. He is a hit man who came off the killing fields alive. He left the business and turned to Christ. And then he decided to tell the story of his life and work. Charles Bowden first encountered El Sicario while reporting for the book "Murder City." As trust between the two men developed, Bowden bore witness to the Sicario's unfolding confession, and decided to tell his story. The well-spoken man that emerges from the pages of "El Sicario" is one who has been groomed by poverty and driven by a refusal to be one more statistic in the failure of Mexico. He is not boastful, he claims no major standing in organized crime. But he can explain in detail not only torture and murder, but how power is distributed and used in the arrangement between the public Mexican state and law enforcement on the ground - where terror and slaughter are simply tools in implementing policy for both the police and the cartels. And he is not an outlaw or a rebel. He is the state. When he headed the state police anti-kidnapping squad in Juarez, he was also running a kidnapping ring in Juarez. When he was killing people for money in Juarez, he was sharpening his marksmanship at the Federal Police range. Now he lives in the United States as a fugitive. One cartel has a quarter million dollar contract on his head. Another cartel is trying to recruit him. He speaks as a free man and of his own free will - there are no charges against him. He is a lonely voice - no one with his background has ever come forward and talked. He is the future - there are thousands of men like him in Mexico and there will be more in other places. He is the truth no one wants to hear.