The post-genomic revolution is witnessing the generation of petabytes of data annually, with deep implications ranging across evolutionary theory, developmental biology, agriculture, and disease processes. "Data Mining for Systems Biology: Methods and Protocols," surveys and demonstrates the science and technology of converting an unprecedented data deluge to new knowledge and biological insight. The volume is organized around two overlapping themes, network inference and functional inference. Written in the highly successful "Methods in Molecular Biology " series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, "Data Mining for Systems Biology: Methods and Protocols" also seeks to aid researchers in the further development of databases, mining and visualization systems that are central to the paradigm altering discoveries being made with increasing frequency."

Acclaimed biomedical scientist Charles DeLisi tells the story of the rewards and frustrations of a life in science. The memoir spans half a century beginning in grade school when we find a somewhat shy boy deeply affected by the profoundly saddening sight of trees and woods in his beloved Bronx neighborhood being displaced by tons of steel and concrete. The reader is taken inside the mind of a complex non-conformist as he struggles with personal tragedy and ambivalence and moves from physics to history back to physics, and eventually into a career as a biomedical scientist. Among the most important parts of the memoir are his personal recollections of the years as director of the Department of Energy's Health and Environmental Research Programs when he fought the mighty battles that would move two Federal Agencies and place the Human Genome Project, including a unique ethical component, on the National Agenda. We watch an uncannily successful strategist and leader; who sees himself as an ordinary person, distinguished only by an intense passion for science, as he and his colleagues successfully engage Congressmen, his superiors at the DOE, and scientists of different backgrounds. The story closes where it began, with environmental change dominating the emotional landscape, as he and his colleagues struggle to fight the battle against a changing climate.

Acclaimed biomedical scientist Charles DeLisi tells the story of the rewards and frustrations of a life in science. The memoir spans half a century beginning in grade school when we find a somewhat shy boy deeply affected by the profoundly saddening sight of trees and woods in his beloved Bronx neighborhood being displaced by tons of steel and concrete. The reader is taken inside the mind of a complex non-conformist as he struggles with personal tragedy and ambivalence and moves from physics to history back to physics, and eventually into a career as a biomedical scientist. Among the most important parts of the memoir are his personal recollections of the years as director of the Department of Energy's Health and Environmental Research Programs when he fought the mighty battles that would move two Federal Agencies and place the Human Genome Project, including a unique ethical component, on the National Agenda. We watch an uncannily successful strategist and leader; who sees himself as an ordinary person, distinguished only by an intense passion for science, as he and his colleagues successfully engage Congressmen, his superiors at the DOE, and scientists of different backgrounds. The story closes where it began, with environmental change dominating the emotional landscape, as he and his colleagues struggle to fight the battle against a changing climate.

This volume contains 31 peer-reviewed papers based on the presentations at the 7th International Annual Workshop on Bioinformatics and Systems Biology (IBSB 2007) held at the Human Genome Center, Institute of Medical Science, University of Tokyo from July 31 to August 2, 2007. This workshop started in 2001 as an event for doctoral students and young researchers to present and discuss their research results and approaches in bioinformatics and systems biology. It is part of a collaborative educational program involving leading institutions and leaders committed to the following programs and partner institutions:* Boston (Charles DeLisi) - Graduate Program in Bioinformatics, Boston University* Berlin (Herman-Georg Holzhutter) - The International Research Training Group (IRTG) "Genomics and Systems Biology of Molecular Networks"* Kyoto/Tokyo (Minoru Kanehisa/Satoru Miyano) - Joint Bioinformatics Education Program of Kyoto University and University of Tokyo.This volume is dedicated to the memory of Prof. Dr. Dr. h.c. Reinhart Heinrich, a former Professor at Humboldt University Berlin and a co-founder of this workshop.

The post-genomic revolution is witnessing the generation of petabytes of data annually, with deep implications ranging across evolutionary theory, developmental biology, agriculture, and disease processes. Data Mining for Systems Biology: Methods and Protocols, surveys and demonstrates the science and technology of converting an unprecedented data deluge to new knowledge and biological insight. The volume is organized around two overlapping themes, network inference and functional inference. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Data Mining for Systems Biology: Methods and Protocols also seeks to aid researchers in the further development of databases, mining and visualization systems that are central to the paradigm altering discoveries being made with increasing frequency.

The Amphipathic Helix is a comprehensive volume discussing amphipathic helices in systems as diverse as serum lipoproteins, lung surfactant, cytotoxic peptides, ion channels, mitochondrial targeting, peptide hormones, G proteins, T-cell recognition, DNA binding proteins, and antifreeze proteins. The book also includes general introductory material that defines amphipathic helices, discusses methods to identify amphipathic helical segments from the amino acid sequence of a protein, illustrates how amphipathic helices can be used in the de novo design of peptide and protein structures, and describes how these helices stabilize protein structures. There is also a section on techniques to determine helix orientation in a membrane environment using polarized attenuated total reflection infrared spectroscopy or solid state NMR spectroscopy. Recent developments on all these topics have been discussed by leading experts in this reference for researchers and students in biochemistry, biophysics, and pharmacology.