One hundred years ago, when Martinus W. Beijerinck in Delft and Friedrich Loeffler on Riems Island discovered a new class of infectious agents in plants and animals, a new discipline was born. This book, a compilation of papers written by well-recognized scientists, gives an impression of the early days, the pioneer period and the current state of virology. Recent developments and future perspectives of this discipline are sketched against a historic background. With contributions by A. Alcami, D. Baulcombe, F. Brown, L. W. Enquist, H. Feldmann, A. Garcia-Sastre, D. Griffiths, M. C. Horzinek, A. van Kammen, H.-D. Klenk, F. A. Murphy, T. Muster, R. O'Neill, P. Palese, C. Patience, R. Rott, H.- P. Schmiedebach, S. Schneider-Schaulies, G. L. Smith, J. A. Symons, Y. Takeuchi, V. ter Meulen, P. J. W. Venables, V. E. Volchkov, V. A. Volchkova, R. A. Weiss, W. Wittmann, H. Zheng

Advances in molecular biology have enabled leaps forward in the determination of virus phylogenetic history. This detailed 1995 book results from the invitation to foremost experts to give essays on aspects of virus biology. Initial chapters cover impacts of viruses and their control. Further chapters detail genetic variation of viruses and the molecular basis of interrelations with hosts. This leads to discussions of interactions with the host at the population level, and their molecular basis and evolution. Seventeen chapters follow, by specialists on particular groups of viruses describing their impact, genetic origins, sources of variation, population genetics and interactions with hosts. Practical virologists will find the chapters on phylogenetic analysis techniques very useful. The adaptive nature of viruses makes this work highly relevant to evolutionists.

This is the first comprehensive review of the world literature on filovirus research and provides the most extensive bibliography of the subject yet published. There is special emphasis on foreign literature that has never been summarized. Every aspect of filovirus research, including their history, epidemiology, clinical picture, pathology, molecular biology, and political aspects are reviewed in detail.

Significant zoonotic diseases have appeared with increasing frequency in recent years. At a symposium held in Galveston, Texas, in March 2004, many outstanding virologists and others presented papers under the broad theme of "emergence." The intent was to elucidate the diseases themselves, the mechanisms by which they have emerged, the publication perception and response to the diseases, and the possibility of prevention or prediction. The papers in this book summarize the talks of this meeting. Among the many timely papers are those by Nobel Prize winner Peter Doherty, influenza epidemiologists Robert Webster and Jeffery Taubenberger, and important contributions by Neal Nathanson, Esteban Domingo, Barry Beaty, David Walker, James Hughes, and others of world expertise.

One hundred years ago, when Martinus W. Beijerinck in Delft and Friedrich Loeffler on Riems Island discovered a new class of infectious agents in plants and animals, a new discipline was born. This book, a compilation of papers written by well-recognized scientists, gives an impression of the early days, the pioneer period and the current state of virology. Recent developments and future perspectives of this discipline are sketched against a historic background. With contributions by A. Alcami, D. Baulcombe, F. Brown, L. W. Enquist, H. Feldmann, A. Garcia-Sastre, D. Griffiths, M. C. Horzinek, A. van Kammen, H.-D. Klenk, F. A. Murphy, T. Muster, R. O'Neill, P. Palese, C. Patience, R. Rott, H.- P. Schmiedebach, S. Schneider-Schaulies, G. L. Smith, J. A. Symons, Y. Takeuchi, V. ter Meulen, P. J. W. Venables, V. E. Volchkov, V. A. Volchkova, R. A. Weiss, W. Wittmann, H. Zheng

African horse sickness virus is a double-stranded RNA virus which causes a non-contagious, infectious arthropod-borne disease of equines and occasionally dogs. Nine distinct, internationally recognised serotypes of the virus have so far been identified. This book is based upon the findings of two programmes funded by the European Commission. It will be of value not only to the specialist research workers but also to veterinary workers dealing with control and to legislators seeking to promote safe international movement of equines. The topics covered include state-of-the-art discussions on diagnostics, vaccines, molecular biology, vector studies, and epidemiology.

Recently, rapid developments have occurred in the field of viral gastroenteritis. This book is an update of fundamental and practical aspects of viral gastroenteritis. Among the various agents that cause viral gastroenteritis, group A rotaviruses and caliciviruses are the focus of this volume because of their clinical impact and the significance of new findings about them.

Positive-strand RNA viruses include the majority of the plant viruses, a number of insect viruses, and animal viruses, such as coronaviruses, togaviruses, flaviviruses, poliovirus, hepatitis C, and rhinoviruses. Works from more than 50 leading laboratories represent latest research on strategies for the control of virus diseases: molecular aspects of pathogenesis and virulence; genome replication and transcription; RNA recombination; RNA-protein interactions and host-virus interactions; protein expression and virion maturation; RNA replication; virus receptors; and virus structure and assembly. Highlights include analysis of the picornavirus IRES element, evidence for long term persistence of viral RNA in host cells, acquisition of new genes from the host and other viruses via copy-choice recombination, identification of molecular targets and use of structural and molecular biological studies for development of novel antiviral agents.

Advances in molecular biology have enabled leaps forward in the determination of virus phylogenetic history. This detailed 1995 book results from the invitation to foremost experts to give essays on aspects of virus biology. Initial chapters cover impacts of viruses and their control. Further chapters detail genetic variation of viruses and the molecular basis of interrelations with hosts. This leads to discussions of interactions with the host at the population level, and their molecular basis and evolution. Seventeen chapters follow, by specialists on particular groups of viruses describing their impact, genetic origins, sources of variation, population genetics and interactions with hosts. Practical virologists will find the chapters on phylogenetic analysis techniques very useful. The adaptive nature of viruses makes this work highly relevant to evolutionists.

Recently, rapid developments have occurred in the field of viral gastroenteritis. This book is an update of fundamental and practical aspects of viral gastroenteritis. Among the various agents which cause viral gastroenteritis, group A rotaviruses and the caliciviruses, are the focus in this volume, because of the clinical impact and significant new findings about these two virus groups.