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This volume of Current Topics in Microbiology and Immunology was
planned in parallel with an EM BO workshop on cell-cell
Interactions in Leukocyte Homing and Differentiation held at the
Basel Institute for Immunology in November 1992, and many of the
workshop speakers have contributed to it. Cell adhesion is one of
the most dynamic fields of biological research and presented in
this book is the current knowledge on the structure and function of
the major families of cell adhesion molecules-the integrins, the
selectins, the immunoglobulin superfamily, and CD44. Complex
interactions between the members of these families mediate diverse
adhesion functions, including leukocyte-leukocyte interactions,
lymphocyte homing, inflammation, and lymphocyte-stromal cell
interaction during hematopoiesis. A great deal of emphasis is
placed on the regulatory elements that control the expression and
function of adhesion molecules. Cytokines not only induce the
expression of certain adhesion molecules, but may also modify their
functional status. For instance, the integrins exist in either an
inactive nonfunctional form or an active functional form, and a
number of intracellular or extracellular stimuli modify integrin
function. This is particularly important during leukocyte binding
to endothelium and transendothelial migration, which proceeds
through a cascade of adhesion events. Although cell adhesion
molecules play an important role in many processes, this book
concentrates on their role within the immune system. A number of
chapters discuss the migration of lymphocytes between hematopoietic
organs such as the thymus, lymph nodes, Peyer's patches, and
spleen.
This is an EXACT reproduction of a book published before 1923. This
IS NOT an OCR'd book with strange characters, introduced
typographical errors, and jumbled words. This book may have
occasional imperfections such as missing or blurred pages, poor
pictures, errant marks, etc. that were either part of the original
artifact, or were introduced by the scanning process. We believe
this work is culturally important, and despite the imperfections,
have elected to bring it back into print as part of our continuing
commitment to the preservation of printed works worldwide. We
appreciate your understanding of the imperfections in the
preservation process, and hope you enjoy this valuable book.
This scarce antiquarian book is included in our special Legacy
Reprint Series. In the interest of creating a more extensive
selection of rare historical book reprints, we have chosen to
reproduce this title even though it may possibly have occasional
imperfections such as missing and blurred pages, missing text, poor
pictures, markings, dark backgrounds and other reproduction issues
beyond our control. Because this work is culturally important, we
have made it available as a part of our commitment to protecting,
preserving and promoting the world's literature.
This scarce antiquarian book is included in our special Legacy
Reprint Series. In the interest of creating a more extensive
selection of rare historical book reprints, we have chosen to
reproduce this title even though it may possibly have occasional
imperfections such as missing and blurred pages, missing text, poor
pictures, markings, dark backgrounds and other reproduction issues
beyond our control. Because this work is culturally important, we
have made it available as a part of our commitment to protecting,
preserving and promoting the world's literature.
This scarce antiquarian book is included in our special Legacy
Reprint Series. In the interest of creating a more extensive
selection of rare historical book reprints, we have chosen to
reproduce this title even though it may possibly have occasional
imperfections such as missing and blurred pages, missing text, poor
pictures, markings, dark backgrounds and other reproduction issues
beyond our control. Because this work is culturally important, we
have made it available as a part of our commitment to protecting,
preserving and promoting the world's literature.
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