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Current knowledge of the etiology of congenital malformations of
the human gastrointestinal tract is covered in this book, prefaced
by some introductory notes on embryological development.
Malformations involving the esophagus, stomach, small and large
intestine, anus and rectum, pancreas, and hepato-billiary system
are covered. There is a focus on covering those malformations for
which a molecular genetic etiology is understood, but other
causations, including environmental exposures, twinning, and
unknown etiology are also included. For completeness, some
disorders are included which are not, strictly, malformations, or
which do not, strictly, involve the gastrointestinal tract. Such
disorders include Hirschsprung disease, congenital diaphragmatic
hernia, omphalocele, and gastroschisis. Suggested approaches to
clinical evaluation of individuals with gastrointestinal
malformations are included.
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