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F. M. MUGGIA When faced with the inadequacies of current cancer
treatment, we prefer to look at what the future may hold. Quite
often, we take for granted the past, preferring research into
totally new areas. However, the persistent development of fertile
soil may yield surprising rewards for those who choose to build on
the knowledge of the past--hence, this symposium on anthracycline
antibiotics. Although the anthracycline antibiotics represent much
of the present and future of cancer treatment, their actual use c
stretches back barely two decades to the pioneering efforts of
Aurelio Di Marco, who characterized the antitumor properties of
daunomycin and adriamycin. * The clinical application of these two
compounds heralded a decade of excitement among oncologists dealing
with pediatric tumors, breast cancer, leukemias, and lymphomas, and
opened new hope for patients afflicted with sar comas and a variety
of other tumors that had been deemed - sistant to chemotherapy.
These successes were tempered with the realization that the
antitumor effect of anthracyclines could be achieved at times only
at the very high price of risking cardiac decompensation and,
almost invariably, with the occurrence of alopecia and other acute
toxicities. This record of past achievements and problems has
slowly given way to a present increasingly illuminated by our
ability to modify the distressing toxicities of these agents.
Detailed clinical studies supplemented by ingenious laboratory
models have gradually elucidated mechanisms and risk factors im
plicated in the cardiomyopathy."
This scarce antiquarian book is a selection from Kessinger
Publishing's Legacy Reprint Series. Due to its age, it may contain
imperfections such as marks, notations, marginalia and flawed
pages. Because we believe this work is culturally important, we
have made it available as part of our commitment to protecting,
preserving, and promoting the world's literature. Kessinger
Publishing is the place to find hundreds of thousands of rare and
hard-to-find books with something of interest for everyone!
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