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This volume covers the latest methods used in clinical
neurochemistry laboratories for both clinical practice and
research. Chapters in this book discuss topics such as techniques
for cerebrospinal fluid (CSF) collection, pre-analytical
processing, and basic CSF analysis; an examination of biomarkers
including ELISA and automated immunochemical assays for amyloid and
tau markers for Alzheimer's disease; the analysis of neurofilaments
by digital ELISA; and an example of successful novel immunoassay
development. In the Neuromethods series style, chapters include the
kind of detail and key advice from the specialists needed to get
successful results in your laboratory. Cutting-edge and thorough,
Cerebrospinal Fluid Biomarkers is a valuable resource for
clinicians and researchers to use in CSF labs and CSF courses.
This volume covers the latest methods used in clinical
neurochemistry laboratories for both clinical practice and
research. Chapters in this book discuss topics such as techniques
for cerebrospinal fluid (CSF) collection, pre-analytical
processing, and basic CSF analysis; an examination of biomarkers
including ELISA and automated immunochemical assays for amyloid and
tau markers for Alzheimer's disease; the analysis of neurofilaments
by digital ELISA; and an example of successful novel immunoassay
development. In the Neuromethods series style, chapters include the
kind of detail and key advice from the specialists needed to get
successful results in your laboratory. Cutting-edge and thorough,
Cerebrospinal Fluid Biomarkers is a valuable resource for
clinicians and researchers to use in CSF labs and CSF courses.
The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in
clinical neurology, not only in the evaluation of inflammatory,
degenerative, and malignant diseases of the nervous system, but
also in the diagnosis of all forms of cerebral and subarachnoidal
bleedings. The CSF can be easily obtained by lumbar puncture and a
set of basic analyses can be conducted using relatively simple
laboratory methods. By combining different CSF parameters, a wide
range of diagnostic entities can be identified. However, properly
interpreting the test results requires a high level of expertise
and cannot be achieved by just reporting on individual analytic
values. This book covers essential aspects of cerebrospinal fluid
analysis and its use in the diagnosis of common neurological
diseases. The first part addresses preclinical aspects such as the
history of CSF, as well as the anatomical, physiological, and
biological background of this valuable fluid. In addition, CSF
collection, its preanalytical and methodological implications, and
the increasing number of disease-specific markers in CSF are
discussed in detail. Lastly, CSF analyses are put into context with
clinical syndromes, demonstrating their diagnostic value in
neurological clinical practice. Cerebrospinal Fluid in Clinical
Neurology helps readers understand the preanalytical and analytical
aspects of CSF diagnostics and offers a valuable reference guide
for interpreting CSF results during the clinical work-up for
neurological patients.
Cerebrospinal Fluid in Neurologic Disorders, Volume 146 provides a
brief overview on the current use of CSF in clinical routine, the
physiology of CSF, and its usefulness and potential as a biomarker.
The second part addresses the main purpose of the volume,
describing CSF from a research perspective in context with the most
important diagnostic entities in neurology. The book's authors
provide insight into the current understanding of CSF changes in
these various conditions and what it tells us about the nature of
neurological diseases. Furthermore, methodological aspects are
discussed, as are shortcomings that need to be addressed. Finally,
the book provides an outlook for potential directions that can be
explored to improve the various aspects of CSF research with the
ultimate goal of being incorporated in clinical practice.
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