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It was not too many years ago that the role of chemotherapy for
head and neck cancer consisted of single-agent methotrexate for
selected patients with recurrent disease. In the past decade,
multiple new agents, high-dose chemotherapy, combinations, and
intra-arterial approaches have been used for the patient with
recurrent disease. Wheeler critically assesses the current status
of these approaches. When oncologists began testing chemotherapy in
the combined modality approach, trials consisted of induction
chemotherapy and use of single agents as radiosensitizers. Although
a great deal has been learned from these trials, benefit in terms
of survival has been marginal. Even more promising may be the
concomitant use of combination chemo therapy and radiation. Taylor
describes the encouraging results as well as the potential.
Induction chemotherapy may have a second important goal in addition
to improving curability-it could be used for organ preservation.
Dimery et al., present the background for this approach in the
patient with laryngeal cancer as well as a description of their
randomized trial for voice preservation. Head and neck squamous
cancers are a heterogeneous group of diseases, and surgeons have
long sought parameters that will help predict outcome."
Cancers of the head and neck are among the most morbid of cancers.
Convention al surgery and/or radiation therapy have a high cure
rate for patients with early stage disease. However, despite
optimal treatment with surgery and radiotherapy, patients with
nodal spread or extensive local disease have a low cure rate. Even
if a cancer is cured, a patient is often left with long-term
debilities from the treatment and/or cancer. The major causes for
decreased survival in patients with advanced head and neck cancer
include local recurrence, distant metastases, and second primaries.
All of these need to be addressed if one is to improve upon the
curability of advanced disease. There are several new techniques,
surgical and radiotherapeutic, designed to improve local control.
Brachytherapy, or interstitial implantation, delivers a high dose
of localized radiation with minimal normal tissue injury. This
technique as discussed by Goffinet, may be even more efficacious
when combined with hyperthermia. New, creative methods of radiation
therapy delivery, such as the use of multiple fractions per day, as
discussed by Parsons and Million, are also contributing to
long-term local control. Laser therapy, discussed by Ossoff and
Nemeroff, provides another tool for treatment of local disease."
Women continue to be underrepresented in the high paying fields of
science, math, and engineering. They receive only about 80% of the
salary of men holding similar jobs in any field and still face
glass ceilings that limit their attainment. How do we educate and
empower girls to surmount these barriers and succeed throughout
their lives? This unique book reveals the kinds of teaching that
engages girls intellectually, fosters their creativity, and
bolsters their confidence. Drawing on descriptions of great lessons
written by nearly 2,000 students and teachers, it offers a
practical, accessible guide to anyone who wants to find better ways
to help young women succeed. The authors review the special
qualities of lessons that resonate with girls and show how they
meet their developmental needs throughout adolescence. They also
show how vital it is that such teaching happen within schools that
help students learn about the numerous ways that gender affects
girls' development. The authors conclude by detailing how school
leaders can create cultures that support this kind of great
learning and teaching.
Women continue to be underrepresented in the high paying fields of
science, math, and engineering. They receive only about 80% of the
salary of men holding similar jobs in any field and still face
glass ceilings that limit their attainment. How do we educate and
empower girls to surmount these barriers and succeed throughout
their lives? This unique book reveals the kinds of teaching that
engages girls intellectually, fosters their creativity, and
bolsters their confidence. Drawing on descriptions of great lessons
written by nearly 2,000 students and teachers, it offers a
practical, accessible guide to anyone who wants to find better ways
to help young women succeed. The authors review the special
qualities of lessons that resonate with girls and show how they
meet their developmental needs throughout adolescence. They also
show how vital it is that such teaching happen within schools that
help students learn about the numerous ways that gender affects
girls' development. The authors conclude by detailing how school
leaders can create cultures that support this kind of great
learning and teaching.
While figures on Black women and girls' degree attainment suggest
that as a group they are achieving in society, the reality is that
their experiences are far from monolithic, that the educational
system from early on and through college imposes barriers and
inequities, pushing many out of school, criminalizing their
behavior, and leading to a high rate of incarceration. The purpose
of this book is to illuminate scholarship on Black women and girls
throughout the educational pipeline. The contributors--all Black
women educators, scholars, and advocates--name the challenges Black
women and girls face while pursuing their education as well as
offer implications and recommendations for practitioners,
policymakers, teachers, and administrators to consider in ensuring
the success of Black women and girls. This book is divided into
four sections, each identifying the barriers Black girls and women
encounter at the stages of their education and offering strategies
to promote their success and agency within and beyond educational
contexts. In Part One, the contributors explore the importance of
mattering for Black girls in terms of redefining success and joy;
centering Black girl literacy pedagogies that encourage them to
thrive; examining how to make STEM more accessible to them; and
recounting how Black girls' emotions and emotional literacy can
either disempower them or promote their sense of agency to navigate
educational contexts. Part Two uncovers the violence directed
toward and the criminalization of Black women and girls, and how
they are situated in educational and justice systems that collude
to fail them. The contributors address incarceration and the
process of rehabilitation and reentry; the outcomes of disciplinary
action in schools on women who pursue college; and describe how the
erasure and disregard of Black women and girls leaves them absent
from the educational policies that deeply affect their lives and
wellbeing. Part Three focuses on how Black women are left to
navigate without resources that could make their collegiate
pathways smoother; covers how hair politics impact their acceptance
in college leadership roles, particularly at HBCUs; illuminates the
importance of social/emotional and mental health for Black
undergraduate women and the lack of adequate resources; and
explores how women with disabilities navigate higher education. The
final part of this book describes transformative approaches to
supporting the educational needs of Black women and girls,
including the use of a politicized ethic of care, intergenerational
love and dialogue, and constructing communities, including digital
environments, to ensure they thrive through their education and
beyond.
While figures on Black women and girls' degree attainment suggest
that as a group they are achieving in society, the reality is that
their experiences are far from monolithic, that the educational
system from early on and through college imposes barriers and
inequities, pushing many out of school, criminalizing their
behavior, and leading to a high rate of incarceration. The purpose
of this book is to illuminate scholarship on Black women and girls
throughout the educational pipeline. The contributors--all Black
women educators, scholars, and advocates--name the challenges Black
women and girls face while pursuing their education as well as
offer implications and recommendations for practitioners,
policymakers, teachers, and administrators to consider in ensuring
the success of Black women and girls. This book is divided into
four sections, each identifying the barriers Black girls and women
encounter at the stages of their education and offering strategies
to promote their success and agency within and beyond educational
contexts. In Part One, the contributors explore the importance of
mattering for Black girls in terms of redefining success and joy;
centering Black girl literacy pedagogies that encourage them to
thrive; examining how to make STEM more accessible to them; and
recounting how Black girls' emotions and emotional literacy can
either disempower them or promote their sense of agency to navigate
educational contexts. Part Two uncovers the violence directed
toward and the criminalization of Black women and girls, and how
they are situated in educational and justice systems that collude
to fail them. The contributors address incarceration and the
process of rehabilitation and reentry; the outcomes of disciplinary
action in schools on women who pursue college; and describe how the
erasure and disregard of Black women and girls leaves them absent
from the educational policies that deeply affect their lives and
wellbeing. Part Three focuses on how Black women are left to
navigate without resources that could make their collegiate
pathways smoother; covers how hair politics impact their acceptance
in college leadership roles, particularly at HBCUs; illuminates the
importance of social/emotional and mental health for Black
undergraduate women and the lack of adequate resources; and
explores how women with disabilities navigate higher education. The
final part of this book describes transformative approaches to
supporting the educational needs of Black women and girls,
including the use of a politicized ethic of care, intergenerational
love and dialogue, and constructing communities, including digital
environments, to ensure they thrive through their education and
beyond.
In the 1950s, ninety-five percent of patients with Hodgkin's
disease, a cancer of lymph tissue which afflicts young adults,
died. Today most are cured, due mainly to the efforts of Dr. Henry
Kaplan. "Henry Kaplan and the Story of Hodgkin's Disease" explores
the life of this multifaceted, internationally known radiation
oncologist, called a "saint" by some, a "malignant son of a bitch"
by others. Kaplan's passion to cure cancer dominated his life and
helped him weather the controversy that marked each of his
innovations, but it extracted a high price, leaving casualties
along the way. Most never knew of his family struggles, his
ill-fated love affair with Stanford University, or the humanitarian
efforts that imperiled him.
Today, Kaplan ranks as one of the foremost physician-scientists in
the history of cancer medicine. In this book Charlotte Jacobs gives
us the first account of a remarkable man who changed the face of
cancer therapy and the history of a once fatal, now curable,
cancer. She presents a dual drama --the biography of this renowned
man who called cancer his "Moby Dick" and the history of Hodgkin's
disease, the malignancy he set out to annihilate. The book recounts
the history of Hodgkin's disease, first described in 1832: the key
figures, the serendipitous discoveries of radiation and
chemotherapy, the improving cure rates, the unanticipated
toxicities. The lives of individual patients, bold enough to
undergo experimental therapies, lend poignancy to the successes and
failures.
Visit the author's website.
In the 1950s, ninety-five percent of patients with Hodgkin's
disease, a cancer of lymph tissue which afflicts young adults,
died. Today most are cured, due mainly to the efforts of Dr. Henry
Kaplan. "Henry Kaplan and the Story of Hodgkin's Disease" explores
the life of this multifaceted, internationally known radiation
oncologist, called a "saint" by some, a "malignant son of a bitch"
by others. Kaplan's passion to cure cancer dominated his life and
helped him weather the controversy that marked each of his
innovations, but it extracted a high price, leaving casualties
along the way. Most never knew of his family struggles, his
ill-fated love affair with Stanford University, or the humanitarian
efforts that imperiled him.
Today, Kaplan ranks as one of the foremost physician-scientists in
the history of cancer medicine. In this book Charlotte Jacobs gives
us the first account of a remarkable man who changed the face of
cancer therapy and the history of a once fatal, now curable,
cancer. She presents a dual drama --the biography of this renowned
man who called cancer his "Moby Dick" and the history of Hodgkin's
disease, the malignancy he set out to annihilate. The book recounts
the history of Hodgkin's disease, first described in 1832: the key
figures, the serendipitous discoveries of radiation and
chemotherapy, the improving cure rates, the unanticipated
toxicities. The lives of individual patients, bold enough to
undergo experimental therapies, lend poignancy to the successes and
failures.
Visit the author's website.
Cancers of the head and neck are among the most morbid of cancers.
Convention al surgery and/or radiation therapy have a high cure
rate for patients with early stage disease. However, despite
optimal treatment with surgery and radiotherapy, patients with
nodal spread or extensive local disease have a low cure rate. Even
if a cancer is cured, a patient is often left with long-term
debilities from the treatment and/or cancer. The major causes for
decreased survival in patients with advanced head and neck cancer
include local recurrence, distant metastases, and second primaries.
All of these need to be addressed if one is to improve upon the
curability of advanced disease. There are several new techniques,
surgical and radiotherapeutic, designed to improve local control.
Brachytherapy, or interstitial implantation, delivers a high dose
of localized radiation with minimal normal tissue injury. This
technique as discussed by Goffinet, may be even more efficacious
when combined with hyperthermia. New, creative methods of radiation
therapy delivery, such as the use of multiple fractions per day, as
discussed by Parsons and Million, are also contributing to
long-term local control. Laser therapy, discussed by Ossoff and
Nemeroff, provides another tool for treatment of local disease."
It was not too many years ago that the role of chemotherapy for
head and neck cancer consisted of single-agent methotrexate for
selected patients with recurrent disease. In the past decade,
multiple new agents, high-dose chemotherapy, combinations, and
intra-arterial approaches have been used for the patient with
recurrent disease. Wheeler critically assesses the current status
of these approaches. When oncologists began testing chemotherapy in
the combined modality approach, trials consisted of induction
chemotherapy and use of single agents as radiosensitizers. Although
a great deal has been learned from these trials, benefit in terms
of survival has been marginal. Even more promising may be the
concomitant use of combination chemo therapy and radiation. Taylor
describes the encouraging results as well as the potential.
Induction chemotherapy may have a second important goal in addition
to improving curability-it could be used for organ preservation.
Dimery et al., present the background for this approach in the
patient with laryngeal cancer as well as a description of their
randomized trial for voice preservation. Head and neck squamous
cancers are a heterogeneous group of diseases, and surgeons have
long sought parameters that will help predict outcome."
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