H Robust design is an advancing technology which aims to achieve the system design purpose under intrinsic random fluctuation and external disturbance. This book introduces several robust design methods, some of which include linear to nonlinear systems and frequency to time domain. This book provides not only a complete theoretical development and application of H robust design over the last three decades, but also an integrated platform for control, signal processing, communication, systems and synthetic biology. Based on the theoretical H robust design results, the authors also give some practical design examples to illustrate the procedure and validate the performance of the proposed H method with computational simulations and tables.

Systems biology sits at the heart of new integrative paradigm in the 21st century, the book could gain an insight into (i) system structure and the mechanism of biological networks such as gene regulation, protein interactions, signalling, and metabolic pathways; (ii) system dynamics of biological networks, which provides an understanding of stability, robustness, and transduction ability through system identification, and through system analysis methods; (iii) system control methods at different levels of biological networks, which provide an understanding of systematic mechanisms to robustly control system states, minimize malfunctions, and provide potential therapeutic targets in disease treatment; (iv) systematic design methods for the modification and construction of biological networks with desired behaviours, which provide system design principles and system simulations for synthetic biology designs and systems metabolic engineering. This book not only describes the current developments in systems biology, systems synthetic biology, and systems metabolic engineering for engineering and biology researchers but also discusses challenges and future prospects for systems biology and the concept of systems biology as an integrated platform for bioinformatics, systems synthetic biology, and systems metabolic engineering.