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During several decades of this century, the classical physiological
studies on the cardiovascular system have greatly improved our
knowledge on the function of this system under normal and
pathological conditions. This knowledge was the basis of the
breakthrough for diagnostic techniques like the Swan-Ganz catheter,
coronary arteriography, left and right heart biopsies, and invasive
measurements of contractility, as well as therapeutic tools
including aortocoronary bypass surgery, percutanous transluminal
coronary angioplasty, and a broad field of pharmacological
interventions for the whole spectrum of cardiovascular diseases,
especially chronic heart failure. It was during the last decade
that the scientific world focused on the evolution of molecular
biology of the cardiovascular system so that cardiovascular
physiology seemed to become less important. Regarding the
myocardium, molecular alterations of important functional proteins
(phenotype changes), as well as signal transduction pathways of
contractility and cardiac growth have been elucidated. The
functional importance of a number of genes has undoubtedly been
proven with the help of transgenic animals. Mechanics and
Energetics of the Myocardium provides an overview for those
researchers and practioners interested in the broad field of
molecular biology and physiology of the cardiovascular system.
During several decades of this century, the classical physiological
studies on the cardiovascular system have greatly improved our
knowledge on the function of this system under normal and
pathological conditions. This knowledge was the basis of the
breakthrough for diagnostic techniques like the Swan-Ganz catheter,
coronary arteriography, left and right heart biopsies, and invasive
measurements of contractility, as well as therapeutic tools
including aortocoronary bypass surgery, percutanous transluminal
coronary angioplasty, and a broad field of pharmacological
interventions for the whole spectrum of cardiovascular diseases,
especially chronic heart failure. It was during the last decade
that the scientific world focused on the evolution of molecular
biology of the cardiovascular system so that cardiovascular
physiology seemed to become less important. Regarding the
myocardium, molecular alterations of important functional proteins
(phenotype changes), as well as signal transduction pathways of
contractility and cardiac growth have been elucidated. The
functional importance of a number of genes has undoubtedly been
proven with the help of transgenic animals. Mechanics and
Energetics of the Myocardium provides an overview for those
researchers and practioners interested in the broad field of
molecular biology and physiology of the cardiovascular system.
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