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Antiestrogens (AE) like tamoxifen belong to the most commonly used
drugs in the therapy of estrogen receptor positive breast cancer.
Nevertheless, relapses frequently occur during treatment indicating
development of drug resistance. Concerning the underlying
mechanisms, the finding of AE induced TGFss in breast cancer cells
appears to be relevant both with respect to TGFss's cell autonomous
function as a mediator of cancer progression and its function as an
immune regulator. To investigate the potential role of tumor
derived, AE induced TGFss as a suppressor of the host's immune
response, heterologous and autologous in vitro assays have been
established in this work. Application of AE led to an impaired
antitumor immune response, which could be restored by a
neutralizing TGFss antibody. The work at hand thus provides
evidence for an AE treatment induced, TGFss driven
immunosuppression in the tumor microenvironment, a mechanism that
could critically contribute to development of AE resistance during
the
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