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The studies described in this book were carried out in the Mo
lecular Neurobiology Group, Department of Neurology, at the
University of Diisseldorf, Germany. The main goal of this work was
to gain an understanding of the mechanisms responsible for neuronal
regeneration failure in the adult mammalian central nervous system
and to learn how they can be influenced. Ap proaches focused on (a)
the identification of the extrinsic cellular and/or molecular
factors that are responsible for regeneration failure in the adult
CNS and (b) the improvement of axonal regeneration by changing the
local environment of the lesioned axons. The stereotactically
transected postcommissural fornix was used as a lesion and
implantation model. This volume of Advances in Anatomy, Embryology
and Cell Biology presents these particular studies on the
degeneration and regeneration of the postcommissural fornix
performed over the past several years. It is hoped that this basic
experimental research will lead to the development of reparative
and neuroprotective strategies useful in the treatment of both
injury to the CNS and neurode generative diseases. This study would
not have been possible without the help of several people. I thank
Prof. H. W. Miiller, head of the Molecular Neurobiology Laboratory,
for his support and for his critical comments on the manuscript;
Dr. G. Wunderlich, Dr. K. Lips, and S. Hermanns for their fruitful
collaboration; Prof. M. Schwab for the generous gift ofIN1
antibodies; Prof. H. -G. Hartwig and G."
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