Ethical Issues in International Biomedical Research is the definitive book on the ethics of research involving human subjects in developing countries. Using 21 actual case studies, it covers the most controversial topics, including the ethics of placebo research in Africa, what benefits should be provided to the community after completion of a research trial, how to address conflicts between IRBs in developed and developing countries, and undue inducement of poor people in developing countries. Each case is accompanied by two expert commentaries, written by many of the worlds leading experts in bioethics as well as new voices with research experience in developing countries. No other volume has this scope. Students in bioethics, public and international health, and ethics will find this book particularly useful.

Interesting and important ethical questions confront researchers, regulators, institutional review boards, support personnel, and research participants committed to the ethical conduct of human subjects research at all stages of research. Questions encompass - but are not limited to - study design, enrolling participants, balancing the clinical needs of participants against the research agenda, ending trials, discharging post-trial obligations, and resolving conflicts. Straightforward solutions to these types of questions are often not found in regulations, ethics codes, or the bioethics literature. These resources may leave room for interpretation, offer conflicting guidance, or simply fail to address particular questions. Ethics consultation, which has been offered in clinical care settings with regularity since the 1980s, has since the turn of the century increasingly been sought in the clinical research context. Because there has only lately been recognition that ethics consultants can play a valuable role helping the research community conduct research in the most ethically informed way, there are many open questions in the field of research ethics consultation including the appropriate role of consultants and the best methods of consultation. The Clinical Center Bioethics Consultation Service has been serving the NIH community of researchers, administrators, healthcare providers, and research participants for more than a decade, conducting nearly 1,000 consultations in that time. In this book, members of the Bioethics Consultation Service reflect on this long track-record and unparalleled range of research ethics consultations to share a collection of their most interesting and informative research ethics consultations and to start a dialogue on remaining open questions. Although the NIH experience is unique, this book focuses on cases - and associated lessons - that are generalizable and valuable for the entire clinical research community. This book will be valuable to ethics consultants, clinical investigators, students and teachers, and others desiring insight into clinical research ethics and ethics consultation.

This book addresses the many ethical issues and extraordinary risks that nurses and others are facing during the COVID-19 pandemic, which creates physical, emotional, and economic burdens, affecting nurses' overall health and well-being. Nurses are essential front-line clinicians across all health care settings and in every nation. The COVID-19 pandemic caused by the novel SARs-CoV-2 virus has affected children, adults, and communities within and across all societies. Nurses, too, have contracted the virus and died from the disease. They have also seen their colleagues, family members, and friends hospitalized or in intensive care units struggling to survive. Nursing's professionalism and disciplinary resolve to care for patients and families amidst confusion, misinformation, and shifting guidelines has been called "heroic" by the public. How much risk should nurses be expected to accept during a pandemic? How do nurses help patients and families find comfort and dignity at the end-of-life? How do we help nurses who are suffering from moral distress and mental health concerns from what they have seen, been asked to do, or are unable to provide? And, how does society move forward from a pandemic that has challenged our basic ethical principles of justice and what is "fair, good and right" in caring for those who need care, including the most vulnerable and nurses themselves? This book addresses these and other ethical concerns that nurses are facing in their day-to-day clinical practice; experiences shared with patients, families, and colleagues. Although this book was written while the pandemic was still raging across the United States and globally, the events needed to be told as they were unfolding. This book helps us to learn from both the successes and failures that are affecting so many across the globe, including those on whom the public relies on to provide quality, compassionate, and expert care when they are sick: nurses.