Extrinsic geometric flows are characterized by a submanifold evolving in an ambient space with velocity determined by its extrinsic curvature. The goal of this book is to give an extensive introduction to a few of the most prominent extrinsic flows, namely, the curve shortening flow, the mean curvature flow, the Gauss curvature flow, the inverse-mean curvature flow, and fully nonlinear flows of mean curvature and inverse-mean curvature type. The authors highlight techniques and behaviors that frequently arise in the study of these (and other) flows. To illustrate the broad applicability of the techniques developed, they also consider general classes of fully nonlinear curvature flows. The book is written at the level of a graduate student who has had a basic course in differential geometry and has some familiarity with partial differential equations. It is intended also to be useful as a reference for specialists. In general, the authors provide detailed proofs, although for some more specialized results they may only present the main ideas; in such cases, they provide references for complete proofs. A brief survey of additional topics, with extensive references, can be found in the notes and commentary at the end of each chapter.

This textbook is a comprehensive overview of the development of cell-based biopharmaceuticals. Beginning with the underlying biology of stem cell and cell-based products, it traces the long and complex journey from preclinical concept to initiation of a pivotal clinical trial and the potential business model behind it.The book also takes into consideration the different regulatory landscapes and their continuous evolution in Europe, North America and other parts of the world. The authors describe a path to manufacture a clinical grade therapeutic that passes all necessary quality measures as a robust and marketable product including an outlook on next generation products and innovative strategies.This reference book is a must-have guide for any professional already active in biopharmaceuticals and anyone interested in getting involved in a scientific, medical or business capacity.

Ricci flow is a powerful technique using a heat-type equation to deform Riemannian metrics on manifolds to better metrics in the search for geometric decompositions. With the fourth part of their volume on techniques and applications of the theory, the authors discuss long-time solutions of the Ricci flow and related topics. In dimension 3, Perelman completed Hamilton's program to prove Thurston's geometrization conjecture. In higher dimensions the Ricci flow has remarkable properties, which indicates its usefulness to understand relations between the geometry and topology of manifolds. This book discusses recent developments on gradient Ricci solitons, which model the singularities developing under the Ricci flow. In the shrinking case there is a surprising rigidity which suggests the likelihood of a well-developed structure theory. A broader class of solutions is ancient solutions; the authors discuss the beautiful classification in dimension 2. In higher dimensions they consider both ancient and singular Type I solutions, which must have shrinking gradient Ricci soliton models. Next, Hamilton's theory of 3-dimensional nonsingular solutions is presented, following his original work. Historically, this theory initially connected the Ricci flow to the geometrization conjecture. From a dynamical point of view, one is interested in the stability of the Ricci flow. The authors discuss what is known about this basic problem. Finally, they consider the degenerate neckpinch singularity from both the numerical and theoretical perspectives. This book makes advanced material accessible to researchers and graduate students who are interested in the Ricci flow and geometric evolution equations and who have a knowledge of the fundamentals of the Ricci flow.

This book gives a presentation of topics in Hamilton's Ricci flow for graduate students and mathematicians interested in working in the subject. The authors have aimed at presenting technical material in a clear and detailed manner. In this volume, geometric aspects of the theory have been emphasized. The book presents the theory of Ricci solitons, Kahler-Ricci flow, compactness theorems, Perelman's entropy monotonicity and no local collapsing, Perelman's reduced distance function and applications to ancient solutions, and a primer of 3-manifold topology. Various technical aspects of Ricci flow have been explained in a clear and detailed manner. The authors have tried to make some advanced material accessible to graduate students and nonexperts. The book gives a rigorous introduction to Perelman's work and explains technical aspects of Ricci flow useful for singularity analysis. Throughout, there are appropriate references so that the reader may further pursue the statements and proofs of the variou