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Systems Metabolic Engineering is changing the way microbial cell
factories are designed and optimized for industrial production.
Integrating systems biology and biotechnology with new concepts
from synthetic biology enables the global analysis and engineering
of microorganisms and bioprocesses at super efficiency and
versatility otherwise not accessible. Without doubt, systems
metabolic engineering is a major driver towards bio-based
production of chemicals, materials and fuels from renewables and
thus one of the core technologies of global green growth. In this
book, Christoph Wittmann and Sang-Yup Lee have assembled the world
leaders on systems metabolic engineering and cover the full story -
from genomes and networks via discovery and design to industrial
implementation practises. This book is a comprehensive resource for
students and researchers from academia and industry interested in
systems metabolic engineering. It provides us with the fundaments
to targeted engineering of microbial cells for sustainable
bio-production and stimulates those who are interested to enter
this exiting research field.
-Morphology of Filamentous Fungi: Linking Cellular Biology to
Process Engineering Using Aspergillus niger, By Rainer Krull,
Christiana Cordes, Harald Horn, Ingo Kampen, Arno Kwade, Thomas R.
Neu, and Bernd Noertemann; -Multi-Scale Spatio-Temporal Modeling:
Lifelines of Microorganisms in Bioreactors and Tracking Molecules
in Cells, By Alexei Lapin, Michael Klann, and Matthias Reuss;
-Impact of Profiling Technologies in the Understanding of
Recombinant Protein Production, By Chandran Vijayendran and Erwin
Flaschel -Engineering the Escherichia coli Fermentative Metabolism,
By M. Orencio-Trejo, J. Utrilla, M.T. Fernandez-Sandoval, G.
Huerta-Beristain, G. Gosset, and A. Martinez; -Modeling Languages
for Biochemical Network Simulation: Reaction vs Equation Based
Approaches, By Wolfgang Wiechert, Stephan Noack, and Atya Elsheikh;
-Impact of Thermodynamic Principles in Systems Biology, By J.J.
Heijnen;
-Integration of Systems Biology with Bioprocess Engineering:
L-Threonine Production by Systems Metabolic Engineering of
Escherichia Coli, By Sang Yup Lee and Jin Hwan Park; -Analysis and
Engineering of Metabolic Pathway Fluxes in Corynebacterium
glutamicum, By Christoph Wittmann; -Systems Biology of Industrial
Microorganisms, Marta Papini, Margarita Salazar, and Jens Nielsen;
-De Novo Metabolic Engineering and the Promise of Synthetic DNA, By
Daniel Klein-Marcuschamer, Vikramaditya G. Yadav, Adel Ghaderi, and
Gregory N. Stephanopoulos; -Systems Biology of Recombinant Protein
Production in Bacillus megaterium, Rebekka Biedendieck, Boyke Bunk,
Tobias Furich, Ezequiel Franco-Lara, Martina Jahn, and Dieter Jahn;
-Extending Synthetic Routes for Oligosaccharides by Enzyme,
Substrate and Reaction Engineering; By Jurgen Seibel, Hans-Joachim
Joerdening, and Klaus Buchholz; -Regeneration of Nicotinamide
Coenzymes: Principles and Applications for the Synthesis of Chiral
Compounds; By Andrea Weckbecker, Harald Groeger, and Werner Hummel;
Systems Metabolic Engineering is changing the way microbial cell
factories are designed and optimized for industrial
production.
Integrating systems biology and biotechnology with new concepts
from synthetic biology enables the global analysis and engineering
of microorganisms and bioprocesses at super efficiency and
versatility otherwise not accessible. Without doubt, systems
metabolic engineering is a major driver towards bio-based
production of chemicals, materials and fuels from renewables and
thus one of the core technologies of global green growth. In this
book, Christoph Wittmann and Sang-Yup Lee have assembled the world
leaders on systems metabolic engineering and cover the full story
from genomes and networks via discovery and design to industrial
implementation practises.
This book is a comprehensive resource for students and researchers
from academia and industry interested in systems metabolic
engineering. It provides us with the fundaments to targeted
engineering of microbial cells for sustainable bio-production and
stimulates those who are interested to enter this exiting research
field.
-Morphology of Filamentous Fungi: Linking Cellular Biology to
Process Engineering Using Aspergillus niger, By Rainer Krull,
Christiana Cordes, Harald Horn, Ingo Kampen, Arno Kwade, Thomas R.
Neu, and Bernd Noertemann; -Multi-Scale Spatio-Temporal Modeling:
Lifelines of Microorganisms in Bioreactors and Tracking Molecules
in Cells, By Alexei Lapin, Michael Klann, and Matthias Reuss;
-Impact of Profiling Technologies in the Understanding of
Recombinant Protein Production, By Chandran Vijayendran and Erwin
Flaschel -Engineering the Escherichia coli Fermentative Metabolism,
By M. Orencio-Trejo, J. Utrilla, M.T. Fernandez-Sandoval, G.
Huerta-Beristain, G. Gosset, and A. Martinez; -Modeling Languages
for Biochemical Network Simulation: Reaction vs Equation Based
Approaches, By Wolfgang Wiechert, Stephan Noack, and Atya Elsheikh;
-Impact of Thermodynamic Principles in Systems Biology, By J.J.
Heijnen;
-Integration of Systems Biology with Bioprocess Engineering:
L-Threonine Production by Systems Metabolic Engineering of
Escherichia Coli, By Sang Yup Lee and Jin Hwan Park; -Analysis and
Engineering of Metabolic Pathway Fluxes in Corynebacterium
glutamicum, By Christoph Wittmann; -Systems Biology of Industrial
Microorganisms, Marta Papini, Margarita Salazar, and Jens Nielsen;
-De Novo Metabolic Engineering and the Promise of Synthetic DNA, By
Daniel Klein-Marcuschamer, Vikramaditya G. Yadav, Adel Ghaderi, and
Gregory N. Stephanopoulos; -Systems Biology of Recombinant Protein
Production in Bacillus megaterium, Rebekka Biedendieck, Boyke Bunk,
Tobias Furich, Ezequiel Franco-Lara, Martina Jahn, and Dieter Jahn;
-Extending Synthetic Routes for Oligosaccharides by Enzyme,
Substrate and Reaction Engineering; By Jurgen Seibel, Hans-Joachim
Jordening, and Klaus Buchholz; -Regeneration of Nicotinamide
Coenzymes: Principles and Applications for the Synthesis of Chiral
Compounds; By Andrea Weckbecker, Harald Groger, and Werner Hummel;
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