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Rapid progress continues to be made in understanding the molecular
and cellular events that comprise B-Iymphocyte differentiation.
This is due in part to the high level of inter est shown by many
investigators from diverse disciplines, who find this subject
suitable for addressing some of the fundamental issues of
immunobiology. B-cell developmen tal models are being extensively
used to investigate cell-cell interactions, molecular mediators of
differentiation and proliferation, differential onset of gene
programs, and gene rearrangement and expression, as well as the
generation of the immune response itself. Not surprisingly,
increased understanding of B-cell differentiation sometimes results
from the application of new techniques that permit greater insight
into the cells comprising the system and the genetic mechanisms by
which these cells express their differentiative potential. However,
experimental strategies based upon the novel application of
established technologies have also led to the clarification of many
issues, as well as to the discov ery of previously unrecognized
problems. One problem, well recognized by those active in the
field, is how to keep up with significant developments as they
appear. The purpose of this book, part of a series devoted to
analysing current issues in biology, is to help overcome this
problem. No attempt at comprehensive cov erage of all of the issues
has been made. Rather, a more thorough analysis of a few topics is
presented."
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