Most of the information on the functional role, structure and molecular biology of creatine kinase is scattered in several hundreds of publications. The editors of this volume invited all authors who are most active at present in experimental research on creatine kinases to summarize their work and make the information easily available to a wider scientific audience, especially to young investigators who are entering this field. Since the functional role of coupled creatine kinases is directly related to the phenomenon of compartmentation and structural organization of metabolic networks, we also invited experts in the related areas to contribute to the volume. Almost all invited authors responded enthusiastically and the results of this collective work are presented here. For biochemists, biophysicists, physiologists, and medical research workers.

This book describes the use of quantitative methods in studies in organized metabolic systems, such as mathematical modeling and Metabolic Control Analysis, for investigation of the problems of bioenergetics of the cell and also presents new experimental results. The following central problems of cellular bioenergetics are the focus of the discussions: the mechanisms of regulation of oxidative phosphorylation in cells in vivo in health and disease, the influence of fine intracellular structural organization on mitochondrial function, the intracellular networks of energy transfer and metabolic feedback signaling, the role of mitochondria in intracellular calcium cycling, and changes in mitochondrial membrane systems and cellular energetics under pathological conditions.Systematic studies from many laboratories presented in this volume convincingly show that many mitochondrial properties, including affinities for mitochondrial creatine kinase and its molecular biology are related to its molecular physiology and functional coupling to adenine nucleotide translocase, as well as its participation, together with the adenylate kinase system, in intracellular energy transfer. The results of the studies of creatine kinase-deficient transgenic mice are summarized and analyzed using mathematical models of the compartmentalized energy transfer, thus combining two powerful new research methods. All these results, together with physiological and NMR data on the cardiac metabolic and mitochondrial responses to workload changes, confirm the concept of metabolic networks of energy transfer and feedback regulation. The papers, mostly review articles, are written by the leading experts in the field who analyze their experience of research and give insights into the future development of this increasingly important area of biological sciences.

Title: Marseille, son passe, son pre sent et son avenir.Publisher: British Library, Historical Print EditionsThe British Library is the national library of the United Kingdom. It is one of the world's largest research libraries holding over 150 million items in all known languages and formats: books, journals, newspapers, sound recordings, patents, maps, stamps, prints and much more. Its collections include around 14 million books, along with substantial additional collections of manuscripts and historical items dating back as far as 300 BC.The HISTORY OF EUROPE collection includes books from the British Library digitised by Microsoft. This collection includes works chronicling the development of Western civilisation to the modern age. Highlights include the development of language, political and educational systems, philosophy, science, and the arts. The selection documents periods of civil war, migration, shifts in power, Muslim expansion into Central Europe, complex feudal loyalties, the aristocracy of new nations, and European expansion into the New World. ++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++ British Library Clapier, Alexandre; 1863. 220 p.; 8 . 10172.ee.16.

Originally published in 1936, as part of the Cambridge Plain Texts series, this volume contains Reflexions et maximes and Reflexions critiques by French writer Luc de Clapiers, Marquis de Vauvenargues (1715-47). The texts are presented in French with a short editorial introduction in English. A short bibliography is also included. This book will be of value to anyone with an interest in Vauvenargues and French literature.