Specially designed computer software is revolutionizing procedures for structured or rational drug design and discovery. The Guidebook on Molecular Modeling in Drug Design serves as a manual for the analysis ofmolecular structure and the correlation of these structures with pharmacological reactions. Intended as an introductory guide for advanced students and professionals with an interest in computer-assisted modeling for drug design and discovery, this bookwill also be of interest to medicinal and organic chemists, pharmaceutical researchers, pharmacologists, and biochemists who want to gain further insight into this rapidly advancing field.
Molecular modeling is assuming an important role in the understanding of three-dimensional aspects in the specificity of drug-receptor interactions at the molecular level. This research area has become a well-established discipline in pharmaceutical research. It has created unprecedented opportunities in assisting medicinal chemists in the design of new therapeutic agents. Advances made in computer hardware and in theoretical medicinal chemistry have brought high-performance computing and graphics tools within reach of most academic and industrial laboratories, facilitating the development of useful approaches to rational drug design.
The Guidebook on Molecular Modeling in Drug Design serves as a manual for the analysis of the molecular structure of biological molecules and drugs and the correlation of these structures with pharmacological actions. Intended as a guide for advanced students and professionals with an interest in computer-assisted modeling for drug design and discovery, this book will also be of interest to medicinal and organic chemists, pharmaceutical researchers, pharmacologists, and biochemists who want to gain further insight into this rapidly advancing field.

The aim of this book is to present review articles describing the latest theoretical and experimental developments in the field of cold atoms and molecules. Our hope is that this series will promote research by both highlighting recent breakthroughs and by outlining some of the most promising research directions in the field.

The aim of this book is to present review articles describing the latest theoretical and experimental developments in the field of cold atoms and molecules. Our hope is that this series will promote research by both highlighting recent breakthroughs and by outlining some of the most promising research directions in the field.

"French Nobel Laureate Claude Cohen-Tannoudji is second to none in his understanding of the modern theory and application of atom-photon interactions. He is also known for his lucid and accessible writing style ... Advances in Atomic Physics is an impressive and wonderful-to-read reference text ... Certainly researchers in the fields of atom-photon interactions and atom traps will want it as a reference on their bookshelves ... A selection of chapters may be of benefit to students: the early chapters for those entering the field, the later chapters for those already doing atom-laser PhD thesis work."Physics TodayThis book presents a comprehensive overview of the spectacular advances seen in atomic physics during the last 50 years. The authors explain how such progress was possible by highlighting connections between developments that occurred at different times. They discuss the new perspectives and the new research fields that look promising. The emphasis is placed, not on detailed calculations, but rather on physical ideas. Combining both theoretical and experimental considerations, the book will be of interest to a wide range of students, teachers and researchers in quantum and atomic physics.

This is a book about laser cooling, a new research field with many potential applications. The authors present an original approach, using the tools and concepts of statistical physics. A new understanding of laser cooling, both intuitive and quantitative, is obtained. The volume also comprises a case study allowing non-Gaussian (Lévy) statistics, a technique being used more frequently in many different fields.

A Thermo-Economic Approach to Energy From Waste provides readers with the tools to analyze the effectiveness of biomass waste conversion into value-added products and how thermochemical conversion methods can be commercialized with minimum environmental impact. The book provides a comprehensive overview of biomass conversion technologies through pyrolysis, including the types of reactors available, reactor mechanisms, and the upgradation of bio-oil. Case studies are provided on waste disposal in selected favelas (slums) of Rio de Janeiro, including data on subnormal clusters and analyses of solid waste in the 37 slums of Catumbi. Step-by-step guidance is provided on how to use a life cycle assessment (LCA) approach to analyze the potential impact of various waste-to-energy conversion technologies, and a brief overview of the common applications of LCA in other geographical locations is presented, including United States, Europe, China, and Brazil. Finally, waste-to-value-added functional catalysts for the transesterification process in biodiesel production are discussed alongside various other novel technologies for biodiesel production, process simulation, and techno-economic analysis of biodiesel production. Bringing together research and real-world case studies from an LCA perspective, the book provides an ideal reference for researchers and practitioners interested in waste-to-energy conversion, LCA, and the sustainable production of bioenergy.

Volume 45 of "Progress in Drug Research" contains eight reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with neuro peptides as native immune modulators, with Calmodulin and with effects of cell stimuli and drugs on cellular activation, with recent advances in benzodiazepine receptor binding studies, with the medicinal chemistry and therapeutic potentials of ligands of the histamine H3 receptor, with Serotonin uptake inhibitors, with computer-aided drug design, with natri uretic hormones and with the recent developments in the chemotherapy of osteoporosis. In the 36 years that PDR has existed, the Editor has enjoyed the valu able help and advice of many colleagues. Readers, the authors of the reviews and, last but not least, the reviewers have all contributed greatly to the success of this series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a series of monographs. So far, it has been the Editor's intention to help disseminate information on the vast domain of drug research, and to provide the reader with a tool with which to keep abreast of the latest developments and trends. The reviews in PDR are useful to the nonspecialist, who can obtain an overview of a particular field of drug research in a relatively short time."

This is a book about laser cooling, a new research field with many potential applications. The authors present an original approach, using the tools and concepts of statistical physics. A new understanding of laser cooling, both intuitive and quantitative, is obtained. The volume also comprises a case study allowing non-Gaussian (Lévy) statistics, a technique being used more frequently in many different fields.

Covering a number of important subjects in quantum optics, this textbook is an excellent introduction for advanced undergraduate and beginning graduate students, familiarizing readers with the basic concepts and formalism as well as the most recent advances. The first part of the textbook covers the semi-classical approach where matter is quantized, but light is not. It describes significant phenomena in quantum optics, including the principles of lasers. The second part is devoted to the full quantum description of light and its interaction with matter, covering topics such as spontaneous emission, and classical and non-classical states of light. An overview of photon entanglement and applications to quantum information is also given. In the third part, non-linear optics and laser cooling of atoms are presented, where using both approaches allows for a comprehensive description. Each chapter describes basic concepts in detail, and more specific concepts and phenomena are presented in 'complements'.

“French Nobel Laureate Claude Cohen-Tannoudji is second to none in his understanding of the modern theory and application of atom-photon interactions. He is also known for his lucid and accessible writing style … Advances in Atomic Physics is an impressive and wonderful-to-read reference text … Certainly researchers in the fields of atom-photon interactions and atom traps will want it as a reference on their bookshelves … A selection of chapters may be of benefit to students: the early chapters for those entering the field, the later chapters for those already doing atom-laser PhD thesis work.�Physics TodayThis book presents a comprehensive overview of the spectacular advances seen in atomic physics during the last 50 years. The authors explain how such progress was possible by highlighting connections between developments that occurred at different times. They discuss the new perspectives and the new research fields that look promising. The emphasis is placed, not on detailed calculations, but rather on physical ideas. Combining both theoretical and experimental considerations, the book will be of interest to a wide range of students, teachers and researchers in quantum and atomic physics.

This volume represents the proceedings (with later additions) of a session held at the EAA Congress, Lyon, in September 2004. The session looked at continuing exchanges between educators and archaeologists, discussing, among other topics, how programmes are successfully organized and viewed in different countries. Papers in French and English.

Maintaining a balance between depth and breadth, the Sixth Edition of Principles of Polymer Systems continues to present an integrated approach to polymer science and engineering. A classic text in the field, the new edition offers a comprehensive exploration of polymers at a level geared toward upper-level undergraduates and beginning graduate students. Revisions to the sixth edition include: A more detailed discussion of crystallization kinetics, strain-induced crystallization, block copolymers, liquid crystal polymers, and gels New, powerful radical polymerization methods Additional polymerization process flow sheets and discussion of the polymerization of polystyrene and poly(vinyl chloride) New discussions on the elongational viscosity of polymers and coarse-grained bead-spring molecular and tube models Updated information on models and experimental results of rubber elasticity Expanded sections on fracture of glassy and semicrystalline polymers New sections on fracture of elastomers, diffusion in polymers, and membrane formation New coverage of polymers from renewable resources New section on X-ray methods and dielectric relaxation All chapters have been updated and out-of-date material removed. The text contains more theoretical background for some of the fundamental concepts pertaining to polymer structure and behavior, while also providing an up-to-date discussion of the latest developments in polymerization systems. Example problems in the text help students through step-by-step solutions and nearly 300 end-of-chapter problems, many new to this edition, reinforce the concepts presented.