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Sequence-specific DNA binding ligands, amongst which triple helix
forming oligonucleotides are the most efficient as yet, represent
promising tools in a number of fields. One of their most promising
applications is as antiviral tools: they can specifically target a
viral gene, even if it is integrated into the host genome, and be
used to specifically inactivate the viral gene or even destroy the
cells harboring this gene. However, from science fiction to science
there remains a gap; and we are at the moment on the threshold of
this fascinating field. Triple Helix Forming Oligonucleotides
considers the different aspects of the design and improvement,
current or future, of these molecules and their structural
analysis, as well as their applications, with special emphasis on
the attempts to obtain biological effects of these potentially
important tools. What emerges is that the current state of the
research is encouraging, and that these molecules are already
useful in some biotechnology applications.
Sequence-specific DNA binding ligands, amongst which triple helix
forming oligonucleotides are the most efficient as yet, represent
promising tools in a number of fields. One of their most promising
applications is as antiviral tools: they can specifically target a
viral gene, even if it is integrated into the host genome, and be
used to specifically inactivate the viral gene or even destroy the
cells harboring this gene. However, from science fiction to science
there remains a gap; and we are at the moment on the threshold of
this fascinating field. Triple Helix Forming Oligonucleotides
considers the different aspects of the design and improvement,
current or future, of these molecules and their structural
analysis, as well as their applications, with special emphasis on
the attempts to obtain biological effects of these potentially
important tools. What emerges is that the current state of the
research is encouraging, and that these molecules are already
useful in some biotechnology applications.
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