Biomolecular computing has emerged as an interdisciplinary ?eld that draws - getherchemistry, computerscience, mathematics, molecularbiology, andphysics. Our knowledge of DNA nanotechnology and biomolecular computing increases dramatically with every passing year. The International Meeting on DNA C- puting has been a forum where scientists with di?erent backgrounds, yet sh- ing a common interest in biomolecular computing, meet and present their latest results. Continuing this tradition, the 10th International Meeting on DNA C- puting(DNA10)focusedonthecurrentexperimentalandtheoreticalresultswith the greatest impact. The meeting took place at the University of Milano-Bicocca, Milan, Italy, from June 7 to June 10, 2004, and it was organized by the University of Milano- Bicocca and the Department of Informatics of the University of Milano-Bicocca. Papersandposterpresentationsweresoughtinallareasthatrelatetobiomole- lar computing, including (but not restricted to): demonstrations of biomolecular computing (using DNA and/or other molecules), theoretical models of biomol- ularcomputing, biomolecularalgorithms, computationalprocessesinvitroandin vivo, analysis and theoretical models of laboratory techniques, biotechnological and other applications of DNA computing, DNA nanostructures, DNA devices such as DNA motors, DNA error evaluation and correction, in vitro evolution, molecular design, self-assembled systems, nucleic acid chemistry, and simulation tools. Authors were asked to choose between two di?erent tracks: Track A - Full paper, for authors who wished to submit a full paper for presentation at DNA10 (oral or poster), and publication in the conference p- ceedings. Track B - One-page abstract, for authors submitting experimental results, and who planned to submit their manuscript to a scienti?c journal, rather than publish it in the conference procee