This book focuses on both theoretical and practical aspects of the “Device-Edge-Cloud continuum”, a development approach aimed at the seamless provision of next-generation cyber-physical services through the dynamic orchestration of heterogeneous computing resources, located at different distances to the user and featured by different peculiarities (high responsiveness, high computing power, etc.). The book specifically explores recent advances in paradigms, architectures, models, and applications for the “Device-Edge-Cloud continuum”, which raises many 'in-the-small' and 'in-the-large' issues involving device programming, system architectures and methods for the development of IoT ecosystem. In this direction, the contributions presented in the book propose original solutions and aim at relevant domains spanning from healthcare to industry, agriculture and transportation.