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Metalloenzymes: From Bench to Bedside offers a thorough overview of
metalloenzymes, spanning biochemical and structural features,
pharmacology, and biotechnological applications. After a brief
overview, international experts in the field discuss a wide range
of magnesium, calcium, zinc, manganese, nickel, iron, copper,
cadmium, molybdenum, and tungsten enzymes, along with catalytic
roles within their active sites. With a uniform approach
throughout, each chapter includes the structure and function of the
enzyme, physiologic and pathologic roles, inhibitors and activators
of the enzyme (and their design), and clinical agents or compounds
applied in medicine and drug discovery. This book enables
scientists across academia and industry to adopt ongoing
metalloenzyme research, and continuous discovery of novel
metalloenzymes, in new life science studies and clinical
applications.
This book reviews new promising drug targets for Neglected Tropical
Diseases (NTDs), with a special focus on antiprotozoal drugs
against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The
book offers a comprehensive overview of the most recent studied
targets, and it outlines classical and new treatments and delivery
strategies. Expert contributors describe new methods of analysis
and bio-prospecting for new compounds, and provide a critical
perspective of the translational process used in the research and
development of new drug candidates. The book will appeal not only
to researchers, students and professionals interested in drug
development to protozoan diseases, but also to medicinal chemists
in general.
Medicinal chemistry is both science and art. The science of
medicinal chemistry offers mankind one of its best hopes for
improving the quality of life. The art of medicinal chemistry
continues to challenge its practitioners with the need for both
intuition and experience to discover new drugs. Hence sharing the
experience of drug research is uniquely beneficial to the field of
medicinal chemistry. Drug research requires interdisciplinary
team-work at the interface between chemistry, biology and medicine.
Therefore, the topic-related series Topics in Medicinal Chemistry
covers all relevant aspects of drug research, e.g.
pathobiochemistry of diseases, identification and validation of
(emerging) drug targets, structural biology, drugability of
targets, drug design approaches, chemogenomics, synthetic chemistry
including combinatorial methods, bioorganic chemistry, natural
compounds, high-throughput screening, pharmacological in vitro and
in vivo investigations, drug-receptor interactions on the molecular
level, structure-activity relationships, drug absorption,
distribution, metabolism, elimination, toxicology and
pharmacogenomics. In general, special volumes are edited by well
known guest editors.
Medicinal chemistry is both science and art. The science of
medicinal chemistry offers mankind one of its best hopes for
improving the quality of life. The art of medicinal chemistry
continues to challenge its practitioners with the need for both
intuition and experience to discover new drugs. Hence sharing the
experience of drug research is uniquely beneficial to the field of
medicinal chemistry. Drug research requires interdisciplinary
team-work at the interface between chemistry, biology and medicine.
Therefore, the topic-related series Topics in Medicinal Chemistry
covers all relevant aspects of drug research, e.g.
pathobiochemistry of diseases, identification and validation of
(emerging) drug targets, structural biology, drugability of
targets, drug design approaches, chemogenomics, synthetic chemistry
including combinatorial methods, bioorganic chemistry, natural
compounds, high-throughput screening, pharmacological in vitro and
in vivo investigations, drug-receptor interactions on the molecular
level, structure-activity relationships, drug absorption,
distribution, metabolism, elimination, toxicology and
pharmacogenomics. In general, special volumes are edited by well
known guest editors.
This book overviews purinergic receptors that are playing key roles
in human and pathophysiological processes. The book elaborates on
how selective P1 and P2 modulators have been developed as
therapeutics for a variety of diseases. It also provides an
overview of current perspectives in the design of purinergic
receptor modulators and future challenges such as the availability
of selective ligands for all receptor subtypes. Divided into 12
chapters, this comprehensive volume also offers a multidisciplinary
perspective on the historical evolution, starting with a chapter
devoted to the roots and early discoveries of adenosine and its
receptors, followed by a twenty-year retrospective on the
synthesis, properties, and functional potential of adenosine
receptor ligands, probes, and functional conjugates. In the next
chapters, experts in the field delve into topics such as the
therapeutic potential of adenosine receptor ligands in wound
healing and fibrosis, the therapeutic benefits of A2A receptor
antagonists, the A2B adenosine receptor as a target for brain
ischemia or demyelination, the development and latest advancements
in clinical trials of A3 adenosine receptor ligands. Other chapters
describe bifunctional tools to study adenosine receptors,
allosteric modulators of adenosine receptors, and new computational
approaches to inspect adenosine receptor-ligand recognition
processes. Furthermore, the book discusses the role of P2X4
receptors in immunity and inflammation. The final chapters
illustrate CD73 inhibitors as antitumor agents, and bacterial
ectonucleotidases as underexplored antibacterial drug targets. This
book is a valuable resource for scholars working in the field of
medicinal chemistry, as well as researchers in the industry,
providing readers with a comprehensive understanding of adenosine
receptor biology and its therapeutic potential.
pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume
Thirteen, provides a detailed overview of the chemosensitizers for
the treatment of cancer spanning from biochemical and structural
features to pharmacology and drug-design, including technological
applications. The book is structured with innovative outlines and a
distinction between experimental and clinical results. The
continuous discovery and assessment of the role played by old/new
synthetic drugs, natural compounds and technological applications
has led to the urgent need of classification in terms of biological
activity, mechanism of action, clinical outcomes, cancer cell lines
sensible to the treatment, and potentialities to better orient
research in this field. Moreover, all the aspects relevant for
medicinal chemistry (drug design, structure-activity relationships,
permeability data, cytotoxicity, appropriate statistical
procedures, and molecular modeling studies) are strictly
considered.
This book reviews new promising drug targets for Neglected Tropical
Diseases (NTDs), with a special focus on antiprotozoal drugs
against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The
book offers a comprehensive overview of the most recent studied
targets, and it outlines classical and new treatments and delivery
strategies. Expert contributors describe new methods of analysis
and bio-prospecting for new compounds, and provide a critical
perspective of the translational process used in the research and
development of new drug candidates. The book will appeal not only
to researchers, students and professionals interested in drug
development to protozoan diseases, but also to medicinal chemists
in general.
Carbonic Anhydrases provides an interdisciplinary review of the
burgeoning carbonic anhydrase (CA) research area, spanning from CAs
classification (biochemical and structural features) to drug design
and pharmacology of CA inhibitors and activators, finally touching
on the biotechnological applications of these metalloenzymes. The
book adopts a clear step-by-step approach and introduction to this
intricate and highly interdisciplinary field. A diverse range of
chapters from international experts speak to CA classification and
distribution, the mechanisms of action and drug design of
inhibitors and activators, the druggability of the various isoforms
in the treatment of a multitude of diseases, and threats to human
health. Carbonic Anhydrases provides biology, biochemistry, and
medicinal chemistry students and researchers a thorough discussion
and update on the evergreen and expanding research area of CAs.
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