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Since 1959, the International Society of Arterial Chemoreception
(ISAC) has organized in a variety of countries fifteen scientific
meetings devoted to the mechanisms of peripheral arterial
chemoreception and chemoreceptor reflexes. After the meeting held
in Philadelphia with Sukhamay Lahiri as president, ISAC membership
elected Lyon (CNRS, University Claude Bernard, France) as the site
of the xv" ISAC Symposium. The Symposium was effectively held in
Lyon from the 18th to the 22nd of November 2002 and Jean-Marc
Pequignot was its president. The organizers were Jean-Marc
Pequignot and Yvette Dalmaz Lyon (CNRS, University Claude Bernard,
France) and the Scientific Committee was formed by John Carroll
(University of Arkansas for Medical Sciences, USA), Constancio
Gonzalez (University of Valladolid, Spain), Prem Kumar (University
of Birmingham, U. K. ), Sukhamay Lahiri (University of
Pennsylvania, Philadelphia, USA), Colin Nurse (McMaster University,
Hamilton, Ontario, Canada), and Nanduri Prabhakar (Case Western
University, Cleveland, Ohio, USA). The Symposium in Lyon intended
to follow the path opened in Philadelphia gathering people working
at the interface of cellular and molecular biology with researchers
in the more classical topics of chemoreception pathways and
reflexes. The aim was to join experts with different perspectives.
Along these lines, some participants are engaged in the exploration
of the intimate mechanisms of oxygen sensing and cellular
responses, with their work centered in a great number of
preparations covering a broad spectrum from bacteria, to
chemoreceptor cells or to central nervous systems neurons.
Arterial chemoreceptors are unique structures which continuously
monitor changes in arterial blood oxygen, carbon dioxide, glucose,
and acid. Alterations in these gases are almost instantaneously
sensed by arterial chemoreceptors and relayed into a physiological
response which restores blood homeostasis. Arterial Chemoreception
contains updated material regarding the physiology of the primary
arterial chemoreceptor; the carotid body. Moreover, this book also
explores tantalizing evidence regarding the contribution of the
aortic bodies, chromaffin cells, lung neuroepithelial bodies, and
brainstem areas involved in monitoring changes in blood gases.
Furthermore this collection includes data showing the critical
importance of these chemoreceptors in the pathophysiology of human
disease and possible therapeutic treatments. This book is a
required text for any researcher in the field of arterial
chemoreception for years to come. It is also a critical text for
physicians searching for bench-to-bedside treatments for heart
failure, sleep apnea, and pulmonary hypertension.
This volume contains the Proceedings of the XVIIth ISAC Meeting
held in Valladolid, Spain, July 1-5, 2008. As such, it contains the
most permanent records of the combined efforts of all attendants.
The meeting was held at the School of Medicine of Valladolid, that
had the privilege of a recent celebration. The celeb- tion was none
other than its 600th anniversary, implying that all participants
were surrounded by historical landmarks, from the historical
building of the University, to the Museum of polychrome sculpture
of Valladolid, to the Monastery of Clarisas in Tordesillas, to the
beauty and charm of Salamanca. In this ambience we had three days
of intense work, distributed in several oral sessions, preceded by
plenary lectures given by our invited speakers who were kind enough
to provide us with the latestprogressintheirspeci c elds. We also
hadtimeallottedtoposterviewing. As regularattendantsto the XVIIth
ISACMeeting, we want to expressourappreciation
forthevaluablediscussionssurroundingeachposter,
theenthusiasticpresentationof data, the comments of colleagues with
suggestions for improvement, and the plans for collaborations that
emerged from these discussions. Needless to say that XVIIth ISAC
Meeting was the fruit of many collabo- tive efforts. The Local
Organizing Committee pro ted from the advice of several colleagues
from around the world, namely, Prof. Chris Peers from Leeds, UK,
Prof. Prem Kumar from Birmingham, UK, Prof. Nanduri Prabhakar from
Chicago, USA, Prof. Colin Nurse from Hamilton, Canada, and Prof.
Rodrigo Iturriaga from Santiago, Chile
Since 1959, the International Society of Arterial Chemoreception
(ISAC) has organized in a variety of countries fifteen scientific
meetings devoted to the mechanisms of peripheral arterial
chemoreception and chemoreceptor reflexes. After the meeting held
in Philadelphia with Sukhamay Lahiri as president, ISAC membership
elected Lyon (CNRS, University Claude Bernard, France) as the site
of the xv" ISAC Symposium. The Symposium was effectively held in
Lyon from the 18th to the 22nd of November 2002 and Jean-Marc
Pequignot was its president. The organizers were Jean-Marc
Pequignot and Yvette Dalmaz Lyon (CNRS, University Claude Bernard,
France) and the Scientific Committee was formed by John Carroll
(University of Arkansas for Medical Sciences, USA), Constancio
Gonzalez (University of Valladolid, Spain), Prem Kumar (University
of Birmingham, U. K. ), Sukhamay Lahiri (University of
Pennsylvania, Philadelphia, USA), Colin Nurse (McMaster University,
Hamilton, Ontario, Canada), and Nanduri Prabhakar (Case Western
University, Cleveland, Ohio, USA). The Symposium in Lyon intended
to follow the path opened in Philadelphia gathering people working
at the interface of cellular and molecular biology with researchers
in the more classical topics of chemoreception pathways and
reflexes. The aim was to join experts with different perspectives.
Along these lines, some participants are engaged in the exploration
of the intimate mechanisms of oxygen sensing and cellular
responses, with their work centered in a great number of
preparations covering a broad spectrum from bacteria, to
chemoreceptor cells or to central nervous systems neurons.
This volume contains the Proceedings of the XVIIth ISAC Meeting
held in Valladolid, Spain, July 1-5, 2008. As such, it contains the
most permanent records of the combined efforts of all attendants.
The meeting was held at the School of Medicine of Valladolid, that
had the privilege of a recent celebration. The celeb- tion was none
other than its 600th anniversary, implying that all participants
were surrounded by historical landmarks, from the historical
building of the University, to the Museum of polychrome sculpture
of Valladolid, to the Monastery of Clarisas in Tordesillas, to the
beauty and charm of Salamanca. In this ambience we had three days
of intense work, distributed in several oral sessions, preceded by
plenary lectures given by our invited speakers who were kind enough
to provide us with the latestprogressintheirspeci c elds. We also
hadtimeallottedtoposterviewing. As regularattendantsto the XVIIth
ISACMeeting, we want to expressourappreciation
forthevaluablediscussionssurroundingeachposter,theenthusiasticpresentationof
data, the comments of colleagues with suggestions for improvement,
and the plans for collaborations that emerged from these
discussions. Needless to say that XVIIth ISAC Meeting was the fruit
of many collabo- tive efforts. The Local Organizing Committee pro
ted from the advice of several colleagues from around the world,
namely, Prof. Chris Peers from Leeds, UK, Prof. Prem Kumar from
Birmingham, UK, Prof. Nanduri Prabhakar from Chicago, USA, Prof.
Colin Nurse from Hamilton, Canada, and Prof. Rodrigo Iturriaga from
Santiago, Chile.
Arterial chemoreceptors are unique structures which continuously
monitor changes in arterial blood oxygen, carbon dioxide, glucose,
and acid. Alterations in these gases are almost instantaneously
sensed by arterial chemoreceptors and relayed into a physiological
response which restores blood homeostasis. Arterial Chemoreception
contains updated material regarding the physiology of the primary
arterial chemoreceptor; the carotid body. Moreover, this book also
explores tantalizing evidence regarding the contribution of the
aortic bodies, chromaffin cells, lung neuroepithelial bodies, and
brainstem areas involved in monitoring changes in blood gases.
Furthermore this collection includes data showing the critical
importance of these chemoreceptors in the pathophysiology of human
disease and possible therapeutic treatments. This book is a
required text for any researcher in the field of arterial
chemoreception for years to come. It is also a critical text for
physicians searching for bench-to-bedside treatments for heart
failure, sleep apnea, and pulmonary hypertension.
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