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In order to produce a superior scholarly treatise in bio medical
science, three important conditions need to be met. First, the
subject needs to be of recognized importance and preferably one in
which a sizeable volume of new knowledge has been added recently.
Second, it needs to be quite evident that the field involved re
quires much more up-to-date coverage than it has received and
third, the choice of the editors and in turn the authors needs to
be recognized as outstanding. This major treatise fills these
criteria in an admirable way. There are few who would deny the
importance of knowledge concerning the circulatory system. This all
pervasive system is the route by which virtually all of the cells
and tissues of the body receive their nutrition and it is the major
route by which metabolic waste products are carried away.
Furthermore, the diseases that involve the circulatory system are,
by far, the underlying causes of death and morbidity in the largest
number of Americans, Western Europeans and several other
populations of industrialized nations. Not only is
atherosclerosis-induced-ischemic disease of the heart, brain and
extremities widespread in these populations but venous occlusive
disease also takes a great toll from phlebothrombosis, pulmonary
embolism, etc.
This is the third volume of the comprehensive series on Struc ture
and Function of the Circulation, edited by Dr. Colin J. Schwartz
with the collaboration of Nicholas T. Werthessen and Stewart Wolf.
Dr. Schwartz, an authority on vascular structure and function and a
respected investigator in this field for many years, selected as
authors for the chapters an outstanding group of scientists from
various parts of the world. As indicated in the Preface, the
impetus for this broad treat ise evolved from the scientific
sessions of three interdisciplinary international conferences held
in Lindau in 1970, in Heidelberg in 1973, and Totts Gap,
Pennsylvania, in 1976 as well as from numerous informal
discussions. The subjects dealt with in these three volumes range
from the roots of our knowledge in ancient history to the most
recent inform ation on contractile proteins of smooth muscle cells.
The structure, distribution, and dynamics of arteries, veins, and
lymphatics are described in chapters on the systemic circulation as
well as that of the heart, the vessels themselves, the brain,
nerves, and viscera. Descriptions of ultrastructure,
histochemistry, metabolism, and func tion of endothelium and of
vascular smooth muscle and of vascular changes in aging are all
included in the vast scope of this under taking.
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