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Free Radicals in ENT Pathology (Hardcover, 2015 ed.): Josef Miller, Colleen G. Le Prell, Leonard Rybak Free Radicals in ENT Pathology (Hardcover, 2015 ed.)
Josef Miller, Colleen G. Le Prell, Leonard Rybak
R5,951 R5,317 Discovery Miles 53 170 Save R634 (11%) Ships in 12 - 19 working days

This comprehensive volume examines the current state of free radical biology and its impact on otology, laryngology, and head and neck function. The chapters collectively highlight the interrelationship of basic and translational studies in each area, define the challenges to translation, and identify the existing basic issues that demand investigation as well as the opportunities for novel intervention to prevent and treat ENT pathology and impairment. In each chapter, or in some cases pairs of chapters, the author(s) have included or married issues of basic research with translational challenges and research, thus defining the pathway by which new basic insights may lead to interventions to prevent or treat impairment. The final chapter of this book reflects a meeting of all the contributors, culminating in a discussion and "white paper" that identifies the challenges to the field and defines the studies and collaborations that may lead to improved understanding of free radical biology in ENT and, subsequently, new interventions to medically treat ENT pathology.

Translational Research in Audiology, Neurotology, and the Hearing Sciences (Hardcover, 1st ed. 2016): Colleen G. Le Prell,... Translational Research in Audiology, Neurotology, and the Hearing Sciences (Hardcover, 1st ed. 2016)
Colleen G. Le Prell, Edward Lobarinas, Arthur N. Popper, Richard R Fay
R4,625 Discovery Miles 46 250 Ships in 12 - 19 working days

Translational Research is the interface between basic science and human clinical application, including the entire process from animal studies to human clinical trials (phases I, II, and III). Translational Research moves promising basic science results from the laboratory to bedside application. Yet, this transition is often the least-defined, least-understood part of the research process. Most scientific training programs provide little or no systematic introduction to the issues, challenges, and obstacles that prevent effective research translation, even though these are the key steps that enable high-impact basic science to ultimately result in significant clinical advances that improve patient outcome. This volume will provide an overview of key issues in translation of research from "bedside to bench to bedside", not only from the perspective of the key funding agencies, but also from the scientists and clinicians who are currently involved in the translational research process. It will attempt to offer insight into real-world experience with intellectual property and technology transfer activities that can help move auditory technologies ahead, as scientists and clinicians typically have little or no formal training in these areas. Translational Research in Audiology and the Hearing Sciences will be aimed at graduate students and postdoctoral investigators, as well as professionals and academics. It is intended to function as a high-profile and up-to-date reference work on Translational Research in the auditory sciences, emphasizing research programs in the traditional areas including drugs and devices, as well as less traditional, still emerging, areas such as sensorineural hearing loss, auditory processing disorder, cochlear implants and hearing aids, and tinnitus therapies.

Noise-Induced Hearing Loss - Scientific Advances (Hardcover, 2012): Colleen G. Le Prell, Donald Henderson, Richard R Fay,... Noise-Induced Hearing Loss - Scientific Advances (Hardcover, 2012)
Colleen G. Le Prell, Donald Henderson, Richard R Fay, Arthur N. Popper
R5,144 Discovery Miles 51 440 Ships in 10 - 15 working days

Exposure to loud noise continues to be the largest cause of hearing loss in the adult population. The problem of NIHL impacts a number of disciplines. US standards for permissible noise exposure were originally published in 1968 and remain largely unchanged today. Indeed, permissible noise exposure for US personnel is significantly greater than that allowed in numerous other countries, including for example, Canada, China, Brazil, Mexico, and the European Union. However, there have been a number of discoveries and advances that have increased our understanding of the mechanisms of NIHL. These advances have the potential to impact how NIHL can be prevented and how our noise standards can be made more appropriate.

Translational Research in Audiology, Neurotology, and the Hearing Sciences (Paperback, Softcover reprint of the original 1st... Translational Research in Audiology, Neurotology, and the Hearing Sciences (Paperback, Softcover reprint of the original 1st ed. 2016)
Colleen G. Le Prell, Edward Lobarinas, Arthur N. Popper, Richard R Fay
R4,866 Discovery Miles 48 660 Ships in 10 - 15 working days

Translational Research is the interface between basic science and human clinical application, including the entire process from animal studies to human clinical trials (phases I, II, and III). Translational Research moves promising basic science results from the laboratory to bedside application. Yet, this transition is often the least-defined, least-understood part of the research process. Most scientific training programs provide little or no systematic introduction to the issues, challenges, and obstacles that prevent effective research translation, even though these are the key steps that enable high-impact basic science to ultimately result in significant clinical advances that improve patient outcome. This volume will provide an overview of key issues in translation of research from "bedside to bench to bedside", not only from the perspective of the key funding agencies, but also from the scientists and clinicians who are currently involved in the translational research process. It will attempt to offer insight into real-world experience with intellectual property and technology transfer activities that can help move auditory technologies ahead, as scientists and clinicians typically have little or no formal training in these areas. Translational Research in Audiology and the Hearing Sciences will be aimed at graduate students and postdoctoral investigators, as well as professionals and academics. It is intended to function as a high-profile and up-to-date reference work on Translational Research in the auditory sciences, emphasizing research programs in the traditional areas including drugs and devices, as well as less traditional, still emerging, areas such as sensorineural hearing loss, auditory processing disorder, cochlear implants and hearing aids, and tinnitus therapies.

Noise-Induced Hearing Loss - Scientific Advances (Paperback, 2012 ed.): Colleen G. Le Prell, Donald Henderson, Richard R Fay,... Noise-Induced Hearing Loss - Scientific Advances (Paperback, 2012 ed.)
Colleen G. Le Prell, Donald Henderson, Richard R Fay, Arthur N. Popper
R3,639 Discovery Miles 36 390 Ships in 10 - 15 working days

Exposure to loud noise continues to be the largest cause of hearing loss in the adult population. The problem of NIHL impacts a number of disciplines. US standards for permissible noise exposure were originally published in 1968 and remain largely unchanged today. Indeed, permissible noise exposure for US personnel is significantly greater than that allowed in numerous other countries, including for example, Canada, China, Brazil, Mexico, and the European Union. However, there have been a number of discoveries and advances that have increased our understanding of the mechanisms of NIHL. These advances have the potential to impact how NIHL can be prevented and how our noise standards can be made more appropriate.

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