This volume contains lectures from the Graduate Summer School ""Quantum Field Theory and Manifold Invariants"" held at Park City Mathematics Institute 2019. The lectures span topics in topology, global analysis, and physics, and they range from introductory to cutting edge. Topics treated include mathematical gauge theory (anti-self-dual equations, Seiberg-Witten equations, Higgs bundles), classical and categorified knot invariants (Khovanov homology, Heegaard Floer homology), instanton Floer homology, invertible topological field theory, BPS states and spectral networks. This collection presents a rich blend of geometry and topology, with some theoretical physics thrown in as well, and so provides a snapshot of a vibrant and fast-moving field. Graduate students with basic preparation in topology and geometry can use this volume to learn advanced background material before being brought to the frontiers of current developments. Seasoned researchers will also benefit from the systematic presentation of exciting new advances by leaders in their fields.

This volume is based on four advanced courses held at the Centre de Recerca Matematica (CRM), Barcelona. It presents both background information and recent developments on selected topics that are experiencing extraordinary growth within the broad research area of geometry and quantization of moduli spaces. The lectures focus on the geometry of moduli spaces which are mostly associated to compact Riemann surfaces, and are presented from both classical and quantum perspectives.