Tamoxifen Tales: Suggestions for Scientific Survival presents a case study describing the academic journey of teams behind major advances in medical sciences, highlighting lessons learned that are applicable to the next generation of scientists. This book provides a manual on the successful mentoring of young scientists, including stories describing how training experience shaped careers to become leaders in academia and the pharmaceutical industry. The book documents Professor V. Craig Jordan's 50-year career in medical sciences that led to the discovery and development of Selective Estrogen Receptor Modulators (SERMs), which became the standard of women's healthcare around the world. Additionally, it illustrates the versatility of a scientist with a commitment to serving societies. This important resource will be a useful and interesting book for established medical scientists, research mentors and advanced students wanting to chart a successful and impactful research career.

Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the "father of tamoxifen" - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a "failed morning after contraceptive" to become the "gold standard" for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen's pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.

Tamoxifen Tales: Suggestions for Scientific Survival presents a case study describing the academic journey of teams behind major advances in medical sciences, highlighting lessons learned that are applicable to the next generation of scientists. This book provides a manual on the successful mentoring of young scientists, including stories describing how training experience shaped careers to become leaders in academia and the pharmaceutical industry. The book documents Professor V. Craig Jordan's 50-year career in medical sciences that led to the discovery and development of Selective Estrogen Receptor Modulators (SERMs), which became the standard of women's healthcare around the world. Additionally, it illustrates the versatility of a scientist with a commitment to serving societies. This important resource will be a useful and interesting book for established medical scientists, research mentors and advanced students wanting to chart a successful and impactful research career.

This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs - tamoxifen and raloxifene - are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.

If the River is Hidden charts the journey of two writers from the source to the mouth of the Bann, Northern Ireland's longest river. Through a dialogue of prose and poetry the history, landscape and divisions that have come to define the North are explored and challenged. With backgrounds from each side of the sectarian divide, theirs is a journey of uncovering a sense of place and of searching for meaning; a reshaping of the authors' own memories, experiences and expectations. For like the river, it is not just what is visible, but what is hidden, that comes to define us.

Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the "father of tamoxifen" - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a "failed morning after contraceptive" to become the "gold standard" for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen's pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.

Pharmacologic interventions to prevent the evolution of human cancers are still in its infancy, although a good number o- mostly controlled - clinical studies have been performed in the past two decades. However, regarding the partially stagnating therapeutic results of major epithelial cancer types such as breast-, lung-, colon- and ENT-cancer types, the problem of in terference with the evolution of disease at a preclinical level is an intriguing one, and the field seems to develop into one of the fastest growing domaines of modern oncology. This process is fa cilitated by the developments of molecular on co-genetics and the gowing existence of family cancer units, allowing to better identi fy and inform respective high risk groups, thus enabling re searchers and clinicians to more realistically target their chemo preventive efforts to the true populations at risk. On this changing background, the newly formed International Society of Cancer Chemoprevention (ISCaC) together with the Swiss Cancer League and the Interdisciplinary Oncology Center of St. Gallen/Switzerland organized an international Symposium in September 1997, inviting basic researchers, epidemiologists and clinical oncologists of related disciplines to discuss pertinent issues of experimental and clinical chemo- and bio-prevention in a scientific workshop.

Welcome to the world of The Nacullians, three generations of one family, living in a brick house in a line of other brick houses. Craig Jordan-Baker's dark comedy charts the tensions and traumas of one family and their relationship with the city they inhabit.

The crew returns to Kings Dominion to discover things have changed in their absence. The program has changed. Master Lin's schemes revealed. Betrayal. Mystery. The secret of the catacombs beneath the school. A reckoning for the corrupt. Our friends try to hold everything together as Freshman finals loom ever closer... Rick Remender and Wes Craig's darkly humorous look at the 1980s underground comes full circle. Collects DEADLY CLASS #36-40

NEEDLE is a true story, though in many ways I still can't believe it actually happened. After all, I'd graduated from a prestigious university, was reared in an affluent home and knew that drugs were for losers. In fact, I'm not even sure when the metamorphosis occurred-when I made the official leap from struggling musician to struggling junky-but it was definitely before I first stuck myself with a needle and began selling liquor camouflaged in fruit juice to underage children of the rich and famous. Of course, that was merely the tip of the illicit iceberg as so much remains hidden in that shadowy world where dope dealers pose as sales associates in drug fronts disguised as clothing boutiques, and chemically dependent cabbies provide shuttle services to junkies on a quest for the perfect fix. But certainly, the veil of deception would eventually be torn away when I was banished to that awful place, that asylum for the wretched, where another horrific decision would seal my fate with the watery wreckage of an international tragedy. *Profits from NEEDLE will be used to eliminate animal cruelty and improve the lives of homeless pets.

While flicking through some photographs of a holiday in the Caribbean in 2009 Craig Jordan was appalled by what he saw, an overweight out of shape middle aged man on a very slippery slope. Craig decided there and then on a campaign to get "Fit for Fifty" and this became his mantra but the question was which sport? Over the next few months he was a regular visitor in the gym and went out and bought a mountain bike but nothing seemed to inspire and getting the journey to get fit seemed destined to fail. On a whim Craig entered a local triathlon and from that moment was hooked on the sport that over the next year took him on an incredible journey across 3 continents, 16 countries meeting and training with the stars of the sport and in the process getting in better shape than he has ever been at any point in his life. An inspiration not only to triathletes but for anyone who believes age is a roadblock to ultimate fitness.