This issue of Physical Medicine and Rehabilitation Clinics, guest edited by Drs Darren Rosenberg and Craig Rovito, will discuss a number of important topics related to Polio. This issue of one of four issues selected each year by series Consulting Editor, Santos Martinez. Topics discussed in this issue include, but are not limited to: epidemiology and working toward eradication; Polio-like diseases, AFM; Approach to fatigue and Energy Conservation; Bracing: upper and lower limb orthoses; NCS/EMG- common neuropathies and considerations for a patient with polio; Joint and back pain; Scoliosis; Respiratory complications; Psychiatric outcomes and approach; Palliative and end of life discussions and considerations; Patient information: resources and community reintegration; and Medical combordities and complications associated with polio.