Metroville was once flooded with superheroes saving the day. One of the greatest was Mr. Incredible, who found himself annoyed by the young chatterbox fanatic of his, Buddy Pine, who referred to himself as 'Incrediboy.' As Mr. Incredible fought crime, he met another legendary hero, Elastigirl and the two superheroes wed. Shortly afterward, a string of lawsuits banned superheroes from ever saving the day again!

15 years later, Mr. Incredible, now known as Bob Parr is itching to become a superhero again. Mrs. Incredible, or Helen Parr, is trying to persuade him not to. Their son, Dash, who has the ability to run extremely quickly, wants to try out for sports, but he can't because of his powers being revealed. Violet, the Parr's daughter, wants to be normal and fit in as a teen. And the baby, Jack-Jack is only itching for a good time.

Then, Bob hears about a top secret assignment regarding a powerful machine attacking Nomanisan Island. Thinking this is his way to become a superhero again, Bob accepts and yet again becomes Mr. Incredible... however, this anonymous villain has a grudge.