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The uniqueness of human architecture is based on interlinkages of
the regulatory systems -neural, endocrine, immune, genetic- but the
molecular mechanisms underlying this network are still incompletely
understood. The endogenous indolergic system is considered as a
protein-neuro-humoral-endocrine informational network resulted from
the chemical and biological structure of some endogenous
biomolecules with indole structure such as tryptophan, serotonin
and melatonin. The endogenous privileged structures, such as the
indole nucleus, can be used to develop active
biological/therapeutic medical compounds, viable, safe and with low
toxicity (endogenous-like). The book "Tryptophan, serotonin,
melatonin- The spectacular triad" avails the latest data regarding
the biochemical and pathophysiological impacts of tryptophan,
serotonin and melatonin, the main indolic endogenous compounds,
along with an exhaustive research upon medicines with indolic
nucleus and the establishment of a complete database with indolic
molecules introduced in therapy, medicines that have demonstrated
the effectiveness in time and also the therapeutic safety.
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