Sustainability is a top priority for organizations and a key strategy in corporate agendas, but the effective deployment of any strategy demands that the strategy is consistent, functional, and aligned. This Handbook advocates sustainability strategies that encompass environmental, social, and economic dimensions at department-level. Split into sections covering business strategies in marketing, innovation and entrepreneurship, operations management and information systems, finance and accounting, and human resources, this Handbook provides a comprehensive view of the development and deployment of sustainability-driven business strategies across an entire organization. The last section uses case studies to provide a better understanding of the features and tools needed to develop and implement a sustainability-driven business strategy in practice. Distinguishing the important role of each functional area, this Handbook will be a key reference for those researching on sustainability-related topics across business and management. Beyond the academic contributions, this Handbook also provides practical guidelines for managers interested in implementing sustainability-driven business strategies in their workplace.