The Atlas of X-Linked Intellectual Disability Syndromes is a comprehensive and up-to-date summary of the clinically distinctive disorders caused by genes on the X chromosome. Clinical and laboratory data on 150 syndromes are presented in a concise and consistent manner. Each syndrome is defined and information is provided on somatic features, growth and development, neurological signs, cognitive performance, imaging and other laboratory findings, and when possible, the nature and localization of the responsible gene. Craniofacial and other somatic findings are extensively illustrated. A differential matrix accompanies each syndrome description to assist the reader in identifying other X-linked syndromes with overlapping features. Individual syndrome entries are supplemented with nineteen appendices that identify syndromes with common features and provide the location or mapping limits and function of the responsible genes. The authors have extensive experience in the clinical and laboratory delineation of X-linked intellectual disability. They have described new syndromes, regionally mapped disease loci on the X chromosome, and identified the genes responsible for X-linked syndromes.

Collection of three British romantic comedies. In 'About Time' (2013), following yet another uneventful New Year's Eve Party, 21-year-old Tim (Domhnall Gleeson) learns a life-changing secret from his father (Bill Nighy). It seems that the men in Tim's family possess the unique ability to travel in time by simply entering a dark space, clenching their fists, and imagining the place they want to be. Armed with this knowledge, Tim decides to leave rural Cornwall behind and move to London to become a lawyer, and in the process, find love. All seems to be going well when he meets and falls for the dazzling Mary (Rachel McAdams), using his newfound abilities to help win the day. But when a mishap in the time travelling manoeuvre threatens his future happiness, Tim soon comes to realise that, above all else, it's how you live your life in the present that really matters. In 'Love Actually' (2003), eight stories involving the love lives of more than a dozen characters are brought together over one Christmas and climax on Christmas Eve; from the recent widower Daniel (Liam Neeson), the failing marriage of Karen (Emma Thompson) and Harry (Alan Rickman), the aging rocker (Nighy) who just wants to get paid (and laid if possible), through to the Prime Minister (Hugh Grant) falling for a member of Number 10's staff (Martine McCutcheon). In 'Notting Hill' (1999), Anna Scott (Julia Roberts) is the world's most famous movie star, whilst divorcee William Thacker (Grant) owns an ailing travel bookstore in his local neighbourhood of Notting Hill. One day Anna buys a book from William's shop and later collides messily with him on a street corner. She accompanies him home to clean herself up, and from there springs an unlikely romance. However, the path of true love is littered with obstacles, not least the media, the adoring fans and the differences in their lifestyles.